SOFTWARE TO AID ASSESSMENT OF MACULAR EDEMA

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$99,958.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43EY014083-01
Award Id:
60186
Agency Tracking Number:
EY014083
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
AUTOQUANT IMAGING, INC., 877 25TH ST, WATERVLIET, NY, 12189
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
TIMOTHY HOLMES
(518) 276-2138
HOLMES@aqi.com
Business Contact:
TIMOTHY HOLMES
(518) 276-2138
HOLMES@AQI.COM
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): Of the 5 percent of North Americans who develop diabetes, 4-15 percent develop macular edema about 8000 per annum register as legally blind. It is simple for the clinician to diagnosis localized (rather than diffuse) edema that has a marked (2 fold or higher) increase in retinal thickness. However, sensitivity to small increases and diffuse edema is not possible. These limits prevent early diagnosis, follow-up monitoring and the accuracy and completeness of laser photocoagulation treatment. A software algorithm is proposed which, in conjunction with scanning laser tomography, will help the physician detect subtle or diffuse increases in thickness by providing and absolute measure of it and by providing a mapping of it over the retinal field of high x, y resolution (about 10 microns). This will help the physicians to see edema early and improve the utility and completeness of laser treatment. Profiles of reflected laser-light intensity, which represent the reflectance of tissue along the z axis (depth into the retina), are collected within a series of optically sectioned images. These profiles are affected by the retinal thickness and have information about the thickness contained within them. They will be processed using a special maximum likelihood parameter estimation algorithm to extract the retinal thickness across the retina, and especially in the region in the around the macula. The objective of this research is to implement prototype software and test this software for feasibility of its principles. The feasibility criterion is based upon showing that the resulting retinal thickness measurements agree with benchmark measurements taken by optical coherence tomography.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government