Hyperspectral and Multi-Modal Retinal Imaging for Assessment of Retinal Laser Damage

Award Information
Agency:
Department of Defense
Branch
Air Force
Amount:
$99,919.00
Award Year:
2009
Program:
SBIR
Phase:
Phase I
Contract:
FA8650-09-M-6995
Award Id:
92745
Agency Tracking Number:
F083-029-0181
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4041 Forest Park Ave., St. Louis, MO, 63108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
176142693
Principal Investigator:
Timothy Holmes
Chief Executive Officer
(314) 615-6921
holmes@lickenbrock.com
Business Contact:
Maria Holmes
Chief Financial Officer
(314) 615-6922
maria@lickenbrock.com
Research Institute:
n/a
Abstract
The Phase I objective is a conceptual design of a hyperspectral/multimodal fundus camera for assessing laser damage. The premise to be ultimately proven in this project is that damage to the fundus, from laser irradiation, may be characterized and detected by reflectance spectra, and by measuring function such as flow and perfusion. The system will incorporate an existing fundus camera model (e.g., Topcon), custom optical components for hyperspectral/multimodal imaging and a computer interface for controlling the custom components. Software will include specialized acquisition for hyperspectral imaging, automated alignment to compensate eye motion, compensation for illumination flicker, correction of nonuniform component spectra, and compensation of other imperfections, algorithms that highlight lesions, deconvolution for improving spatial and spectral resolving power, and algorithms for detecting flow and perfusion changes. In Phase II, the prototype instrument will be built and tested with NHPs and/or humans in collaboration with Brooks AFB. Tests with NHPs in detecting and characterizing laser-induced damage will be carried out. In Phase III the commercial-ready models will be produced, first, for military applications, and secondly for private sector clinical applications. Private sector applications include AMD, diabetic retinopathy, glaucoma and related conditions. BENEFIT: The most immediate military benefit will be the capability of diagnosing or comfirming laser damage to retinas/fundi. Commercial applications are in clinical diagnosis and treatment of AMD, diabetic retinopathy and glaucoma, among others.

* information listed above is at the time of submission.

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