Short-Wavelength Countermeasure for Circadian Desynchrony

Award Information
Agency:
Department of Defense
Branch
Air Force
Amount:
$99,969.00
Award Year:
2007
Program:
STTR
Phase:
Phase I
Contract:
FA9550-07-C-0111
Award Id:
83336
Agency Tracking Number:
F074-015-0066
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
333 Parkland Plaza Drive, Suite 700, Ann Arbor, CA, 48103
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
036950975
Principal Investigator:
H.Heller
Professor
(650) 723-1509
hcheller@stanford.edu
Business Contact:
CharlesHixson
President
(734) 332-3777
carlosdelnorte@sbcglobal.net
Research Institute:
STANFORD UNIV.
Blanca Rebuelta
Office of Sponsored Research
651 Serra Mall
Stanford, CA, 94305 6203
(650) 725-0515
Nonprofit college or university
Abstract
Exposure to light at critical phases of the circadian cycle is the main stimulus that phase shifts and entrains circadian rhythms. Whereas previous work has concluded that exposure of humans to bright light for an hour or more at the right phase of the circadian cycle produces significant phase shifts of circadian rhythms, and can speed recovery from jet-lag thus facilitating restorative sleep. Our work on mice has produced the unexpected result that exposure of the animals to intermittent millisecond flashes of light distributed over an hour for a total of only 120 msec. of light can produce maximum phase shifts. We have also shown that the effects of light on the circadian system of mice is mediated through a unique photopigment - melanopsin, and the properties of this system explain the effectiveness of brief flashes of light as entraining signals. We propose a proof of concept study to demonstrate whether or not millisecond flashes of light can phase shift the human circadian system. On the basis of these results, we will develop a phase shifting device for military and commercial applications.

* information listed above is at the time of submission.

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