Novel human anti-uPAR antibodies for the treatment of pancreatic cancer

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$158,025.00
Award Year:
2009
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA137884-01A1
Award Id:
93514
Agency Tracking Number:
CA137884
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
AVANTGEN, INC., 12240 KATYDID CIR, SAN DIEGO, CA, 92129
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
186489899
Principal Investigator:
XIAOMIN FAN
(858) 538-9866
XFAN@AVANTGEN.COM
Business Contact:
CATHERINE WOODS
() -
cmwoods@avantgen.com
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): Cancers that are typically diagnosed as late-stage, metastatic disease, such as pancreatic cancer, have remained refractory to standard radiation, surgical and chemotherapy. With all the advance of newer more targeted a gents, pancreatic cancer 5-year mortality rates remain a dismal 93% underscoring the urgent need to identify targets that can be used to block the metastatic process. The uPA system has shown promise as one such target. However, a major limitation of pre-c linical studies is that metastasis involves both tumor and surrounding stromal tissue-derived uPA and its receptor, uPAR. We plan to use a proprietary yeast display library and competitive screening method to try and identify antibodies that can block both human and mouse uPAR and uPA and then test each antibody in an orthotopic model of pancreatic cancer, both as individual monotherapies and in combination with gemcitabine, to evaluate their relative efficacy as inhibitors of the metastatic process. PUBLIC HEALTH RELEVANCE: Despite the progress that has been made over the past 10 to 20 years in identifying cancer treatments that are less toxic than standard chemotherapy, there has been little success in improving the outcome of patients who are diagnosed wi th advanced, late-stage disease that has spread throughout the body (metastatic disease). The goals of this application are to generate very potent antibodies directed against two components of a system, the so-called urokinase system, that appears to play a major role in the invasive processes underlying cancer spread and metastasis and test them in a model of pancreatic cancer. If they prove successful in these pre-clinical models, these antibodies can be directly developed into novel therapeutic agents f or treatment of human pancreatic cancer.

* information listed above is at the time of submission.

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