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Avian transgenesis via site-directed integration

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 2R44GM068139-02
Agency Tracking Number: GM068139
Amount: $746,264.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: PHS2005-2
Solicitation Year: 2005
Award Year: 2005
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
Avigenics, Inc., Georgia Biobusiness Center, Athens, GA, 30605
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (706) 227-1170
Business Contact
Phone: (706) 227-1170
Research Institution
DESCRIPTION (provided by applicant): This Phase II SBIR project describes a novel method to create transgenic poultry that will produce biopharmaceutical proteins in their eggs. Chickens are able to produce large amounts of protein in their eggs at relatively low cost. We seek to harness this capability to synthesize pharmaceutical proteins, such as humanized monoclonal antibodies, that are needed in large amounts. The efficiency of transgenesis in chickens, particularly with large transgenes, is exceedingly low. We propose here to overcome this hurdle by the use of integration-promoting enzymes which are able to recombine specific DMA sequences with a high efficiency. In Phase II of this project, the integration-promoting enzymes will be used to insert transgenes encoding pharmaceutical proteins, and driven by egg white specific promoters, into the genome of chickens. This novel technology will expedite the creation of chickens that can produce Pharmaceuticals, thereby facilitating drug development, enhancing clinical trials and lowering the cost of Pharmaceuticals.

* Information listed above is at the time of submission. *

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