Cost-effective MHz rate Optical Coherence Tomography for biomedical applications

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43EB019266-01
Agency Tracking Number: R43EB019266
Amount: $235,005.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIBIB
Solicitation Number: PA14-077
Solicitation Year: 2017
Award Year: 2014
Award Start Date (Proposal Award Date): 2014-08-01
Award End Date (Contract End Date): 2015-12-01
Small Business Information
1305 NORTH 1000 WEST, Logan, UT, 84321-6801
DUNS: 034399936
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (919) 544-7785
Business Contact
Phone: (435) 752-4301
Research Institution
DESCRIPTION provided by applicant During this SBIR Phase I project we propose to build and test in phantoms a prototype of an innovative cost effective Optical Coherence Tomography OCT system with a X increase in acquisition rate compared to commercially available systems Further development may add an additional X increased acquisition rate for a total of X Current market demand for Mega in depth profiles A scans per second OCT in biomedical applications is driven by the inability of current A scans second OCT systems to provide motion free D images and to cover target area within allowable imaging times Increasing imaging speed to MHz rates also enables functional imaging that is not currently possible Finally MHz imaging speed means less suffering for patients and faster exams means less cost for both patients and insurance companies that will lead to wider acceptance of the OCT imaging in biomedical and clinical applications There are research OCT systems with MHz acquisition rates from two groups one in Germany and one in Japan These systems have shown the value through dramatic imaging improvements available with MHz rate OCT However these research MHz rate OCT systems are currently too expensive and unstable for commercialization Furthermore the designs being implemented do not have a clear development trajectory to commercial viability Therefore a novel approach to MHz OCT is needed We believe our design approach combines the needed system performance with a clear path to successful commercialization Social benefits of this project include the commercialization of a new product with broad biomedical clinical and industry impact Improved imaging capabilities has a great potential to improve our quality of life by first improving the outcome of devastating diseases including blindness cancer cardiovascular diseases among others and secondly by enabling better quality in pharmacy coating quality and micro elements PUBLIC HEALTH RELEVANCE The objective of this project is to create and test in scattering and wide area microstructure phantoms a proof of principle prototype of an innovative straightforward and cost effective MHz range Optical Coherence Tomography OCT system We will construct a benchtop OCT device prototype capable of providing depth profiles A scans at a repetition rate of MHz and featuring an imaging depth of mm and a resolution of m in air with sensitivity exceeding dB The broader commercial impact of the proposed project will be wider acceptance of OCT as a reliable diagnostic tool in ophthalmology and intravascular imaging as well in other areas of biomedicine and industry

* Information listed above is at the time of submission. *

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