High-Throughput Brain Injury Proteomic Microassay

Award Information
Agency:
Department of Defense
Branch
Office of the Secretary of Defense
Amount:
$99,685.00
Award Year:
2005
Program:
STTR
Phase:
Phase I
Contract:
W81XWH-05-C-0168
Agency Tracking Number:
O054-003-2011
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Daimonion Diagnostics, Llc
12085 Research Drive, Alachua, FL, 32615
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
168789274
Principal Investigator:
Monika Oli
Senior Scientist
(386) 418-1632
moli@banyanbio.com
Business Contact:
Ken Walz
Chief Fiancial Officer
(410) 357-9485
kwalz@banyanbio.com
Research Institution:
UNIV. OF FLORIDA
Kevin Wang
PO Box 100256
Gainesville, FL, 32610
(352) 392-3681
Nonprofit college or university
Abstract
Traumatic brain injury (TBI) is a leading cause of combat casualty. Previous estimates for 20th century conflicts were that 15 - 25% of all injuries were sustained to the head. However, with the increased incidence of blast injuries that military personnel are suffering in the current conflicts in Afghanistan and Iraq, head injury is becoming an even more frequent occurrence. Far forward medics need a device to objectively and quantifiably diagnose brain injury in order to effectively triage and provide appropriate treatment to their casualties, thereby providing for improved long-term outcome. The overall objective of this STTR topic is to develop a hand-held point-of-care device for analyzing biomarkers of brain injury that can be used as a diagnostic and triage tool by military medics on the battlefield. This Phase I proposal will establish the feasibility of adapting standard Enzyme-linked immunosorbent assays (ELISAs) of three brain injury biomarkers into an automated miniaturized, multiplexed assay panel using antibody microarray technology. The proposal combines the expertise of the University of Florida in identifying and validating biomarkers of brain injury, of Banyan Biomarkers in developing and optimizing ELISAs for these biomarkers, and of Clinical Microarrays (CMA) in adapting ELISA technology into their patented biochip format.

* information listed above is at the time of submission.

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