High-Throughput Brain Injury Proteomic Microassay

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-05-C-0168
Agency Tracking Number: O054-003-2011
Amount: $99,685.00
Phase: Phase I
Program: STTR
Awards Year: 2005
Solicitation Year: 2005
Solicitation Topic Code: OSD05-T003
Solicitation Number: N/A
Small Business Information
12085 Research Drive, Alachua, FL, 32615
DUNS: 168789274
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Monika Oli
 Senior Scientist
 (386) 418-1632
Business Contact
 Ken Walz
Title: Chief Fiancial Officer
Phone: (410) 357-9485
Email: kwalz@banyanbio.com
Research Institution
 Kevin Wang
 PO Box 100256
Gainesville, FL, 32610
 (352) 392-3681
 Nonprofit college or university
Traumatic brain injury (TBI) is a leading cause of combat casualty. Previous estimates for 20th century conflicts were that 15 - 25% of all injuries were sustained to the head. However, with the increased incidence of blast injuries that military personnel are suffering in the current conflicts in Afghanistan and Iraq, head injury is becoming an even more frequent occurrence. Far forward medics need a device to objectively and quantifiably diagnose brain injury in order to effectively triage and provide appropriate treatment to their casualties, thereby providing for improved long-term outcome. The overall objective of this STTR topic is to develop a hand-held point-of-care device for analyzing biomarkers of brain injury that can be used as a diagnostic and triage tool by military medics on the battlefield. This Phase I proposal will establish the feasibility of adapting standard Enzyme-linked immunosorbent assays (ELISAs) of three brain injury biomarkers into an automated miniaturized, multiplexed assay panel using antibody microarray technology. The proposal combines the expertise of the University of Florida in identifying and validating biomarkers of brain injury, of Banyan Biomarkers in developing and optimizing ELISAs for these biomarkers, and of Clinical Microarrays (CMA) in adapting ELISA technology into their patented biochip format.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government