Regional Flow Imaging by Fluorescent Microspheres

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$596,945.00
Award Year:
1995
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
22340
Agency Tracking Number:
22340
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
6307 Tamoshan Drive, NW, Olympia, WA, 98502
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Clyde H. Barlow
(206) 866-1244
Business Contact:
() -
Research Institute:
n/a
Abstract
We will develop a new approach to the evaluation of microregional circulation. This research is based on the working hypothesis that fluorescent microspheres can be spatially located by fluorescence imaging of organ serial sections. The project will develop instrumentation and procedures to evaluate regional flow in an entire organ. During Phase I, a computer-controlled imaging system will be assembled and images of fluorescent microspheres embedded in perfused rat hearts will be taken. Data analysis procedures will be developed to determine microregional flow characteristics. Phase I studies will demonstrate the feasibility of the working hypothesis and provide design parameters for imaging systems to be constructed during Phase II for use with larger hearts. This project will provide researchers with the instrumentation to rapidly and automatically evaluate microregional flow in tissue using the same procedures involved in radioactive microsphere flow determinations.

* information listed above is at the time of submission.

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