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Universal amplifier system for high-fidelity multi-modal biosignal recordings

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AT008649-01A1
Agency Tracking Number: R41AT008649
Amount: $257,387.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 213
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): 2014-09-01
Award End Date (Contract End Date): 2016-08-31
Small Business Information
351 W 10TH ST, Indianapolis, IN, 46202-4118
DUNS: 078756593
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 WILLIAM COMBS
 (317) 274-5935
 wicombs@iupui.edu
Business Contact
 JOSEPH TREBLEY
Phone: (317) 274-5935
Email: jtrebley@iu.edu
Research Institution
 INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
 980 Indiana Avenue
Lockfield Village, RM 2232
INDIANAPOLIS, IN, 46202-2915
 Nonprofit college or university
Abstract
DESCRIPTION provided by applicant The measurement monitoring and use of bioelectric signals has evolved from the measurement of the electrical activity of the heart to encompass tissues ranging from cardiac skeletal and smooth muscles to brain and peripheral nerve tissues Together with this development has been the evolution of specialized equipment to capture and interpret these minute signals However the future of bioelectric signals measurement is moving towards the measurement and integration of multiple sources and multiple locations which leads to the problem of the need to integrate signals and sources through specialized equipment designed for specific signals To overcome this problem Refer Input R i and its research partners at Indiana University Purdue University IUPUI designed novel bioelectric compander system following a reanalysis of the measurement and acquisition problem The resulting Universal Invertible Amplifier system plays to the strengths of the analog and digital world to span the range of all bioelectric signals coupled with the ability o refocus to specific signals without hardware reconfiguration In this STTR R i and its research partner at IUPUI will further develop this technology and demonstrate feasibility Phase I Specific Aims are Develop and implement the hardware platform Develop and implement the software platform and Complete in vivo validation of the hardware and software system The validated and tested UIA system will form the foundational instrumentation basis upon which a multi modal multi frequency applications will be developed in Phase II This system takes advantage of the universality of the hardware and the real time refocus abilities of the UIA system for which a considerable commercial market exists The system will simplify the instrumentation needs of research and clinical laboratories reducing costs through convergence to a single common recording platform PUBLIC HEALTH RELEVANCE The future of biosignal recordings will see the need for the integration and simultaneous acquisition of distributed multi modal multi source signals This project aims to develop and validate a novel universal bioamplifier system in its ability to faithfully capture signals without distortion or loss and demonstrate its ability to refocus analyis on previously recorded data

* Information listed above is at the time of submission. *

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