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Targeted Nanoparticles of Bismuth Organo Complexes for Spectral CT Imaging of Cor

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 4R42HL112518-03
Agency Tracking Number: R42HL112518
Amount: $992,524.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: NHLBI
Solicitation Number: PA11-097
Timeline
Solicitation Year: 2015
Award Year: 2014
Award Start Date (Proposal Award Date): 2014-08-01
Award End Date (Contract End Date): 2016-07-31
Small Business Information
7964 Arjons Drive, Suite G, San Diego, CA, 92126-4392
DUNS: 155516987
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Y WANG
 (858) 689-8808
 awang@oceannanotech.com
Business Contact
 Y BU
Phone: (479) 251-9988
Email: alicebu@oceannanotech.com
Research Institution
 UNIVERSITY OF WASHINGTON
 4333 Brooklyn Ave NE
Box 359472
Seattle, WA, 98195-9472
 Nonprofit college or university
Abstract
DESCRIPTION provided by applicant Chest pain in patients presenting to the emergency department ED present a clinical dilemma transfer for emergent coronary revascularization admit overnight for cardiac telemetry and stress testing or discharge home with medical follow up In this proposal we hypothesize that a novel thrombus specific Spectral Computed Tomography Multicolored CT nanoparticle i e NanoK approach for direct rapid assessment of coronary disease in the ED could help resolve this clinical dilemma This project which is led by Ocean NanoTech in collaboration with Washington University will complete development of a GLP GMP ready fibrin NanoK product candidate suitably advanced for GLP stability and toxicity testing to support an FDA IND This NanoK platform technology offers unique benefits for diagnosis and treatment of acute coronary disease that could improve healthcare outcomes and reduce costs Chest pain in patients presenting to the emergency department ED present a clinical dilemma transfer for emergent coronary revascularization admit overnight for cardiac telemetry and stress testing or discharge home with medical follow up While the emergent need for cardiac catheterization is self evident from the presentation of some individuals the determination of whether to admit or discharge a patient with an equivocal history and physical is often problematic In lieu of missing a critical cardiac diagnosis patients are admitted for myocardial evaluation and stress testing which is inconvenient costly and unnecessary in the majority of cases In this proposal we hypothesize that a novel thrombus specific Spectral Computed Tomography Multicolored CT nanoparticle i e NanoK approach for direct rapid assessment of coronary disease in the ED could help resolve this clinical dilemma This project describes the demonstration of the prototype concept in Phase and the development demonstration and characterization of the clinical product candidate in Phase II The overarching goal of this project which is led by Ocean NanoTech in collaboration with Washington University will be to complete development of a GLP GMP ready fibrin NanoK product candidate suitably advanced for GLP stability and toxicity testing to support an FDA IND This NanoK platform technology offers unique benefits for diagnosis and treatment of acute coronary disease that could improve healthcare outcomes and reduce costs

* Information listed above is at the time of submission. *

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