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Antimicrobial Coatings to Reduce Hospital Infections

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43GM110895-01A1
Agency Tracking Number: R43GM110895
Amount: $143,702.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: 300
Solicitation Number: PA14-071
Timeline
Solicitation Year: 2015
Award Year: 2015
Award Start Date (Proposal Award Date): 2015-08-01
Award End Date (Contract End Date): 2017-01-31
Small Business Information
12345 W 52ND AVE
Wheat Ridge, CO 80033-1916
United States
DUNS: 181947730
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 GIRISH SRINIVAS
 (303) 940-2321
 gsrinivas@tda.com
Business Contact
 JOHN WRIGHT
Phone: (303) 940-2300
Email: jdwright@tda.com
Research Institution
N/A
Abstract

DESCRIPTION provided by applicant To combat Healthcare Associated Infection HAI which is now the rd leading cause of death in the U S TDA Research Inc proposes to develop new antimicrobial copper alloy coatings for high touch stainless steel surfaces that may be responsible for of all HAI Low cost durable coatings will be scientifically designed for the catalytic production of hydroxyl radicals OH which have the highest oxidation reduction potential V of any non fluorinated species in water surpassing that of all common disinfectants ozone V hydrogen peroxide V hypochlorous acid V and chlorine dioxide V The extreme oxidizing potential of hydroxyl radicals allows destruction of bacterial and fungal cell walls as well as spore and virus coatings Copper provides a variety of other kill mechanisms including binding to microbial defensive enzymes including catalase In moist environments Cu and Cu ions diffuse and displace Na and K in cell membrane ion channels destroying their semi permeable properties and causing microorganisms to rupture Clinical trials unambiguously demonstrate that of Healthcare Acquired Infection in intensive care units is eliminated by replacing only a few of the most frequently touched objects in patient rooms bed side rails nurse call buttons visitor chair arm rests over bed tra tables and IV posts with pure copper Further the clinical data shows that copper retains antimicrobial activity in real world hospital settings and is not deactivated by normal handling Although proven extremely effective replacing all hospital high touch items with fixtures of solid
copper is cost prohibitive Moreover pure copper quickly corrodes and is too soft to resist abrasion To address these issues TDA Research Inc proposes to develop cost effective methods to deposit thin films m thick of copper alloys specifically onto existing stainless steel surfaces that comprise roughly half of the high touch surfaces prevalent in hospitals but which possess little or no antimicrobial properties The copper alloys will be developed for adhesion resistance against corrosion and abrasion ease of application and will be doped to maximize the catalytic production of hydroxyl radicals In Phase I standard protocols required for the registration of anti microbial copper under the Federal Insecticide Fungicide and Rodenticide Act will be followed explicitly This involves testing of andquot x andquot coupons against the five pathogens Staphylococcus aureus American Type Culture Collection ATCC a methicillin resistant strain of S aureus ATCC pathogenic Escherichia coli O H ATCC Enterobacter aerogenes ATCC and Pseudomonas aeuginosa ATCC As controls uncoated stainless steel pure copper and stainless steel coated with pure copper will be tested Phase I research will be considered a success if the microbial burden is reduced a minimum of log relative to uncoated samples as required by the standard protocol simultaneously meeting ASTM Elcometer scratch tests and a cycle Taber pumice Cl corrosion wear test ASTM D to withstand an equivalent of hand touches while reducing costs

PUBLIC HEALTH RELEVANCE According to statistics of the Center for Disease Control of all U S patients now acquire communicable diseases from healthcare environments and every minutes a patient dies from such infection while an additional million annual non fatal cases suffer great loss of quality of life and incur costs estimated at $ billion per year for treatment and rehabilitation Healthcare associated illness is now the rd leading cause of death in the U S exceeded by only cancer and heart attack Pathogen contaminated high touch surfaces are responsible for nearly of such infections which this research will address by developing new anti microbial copper alloys that are catalytic for production of highly oxidizing and disinfecting hydroxyl radicals capable of destroying all classes of pathogen including bacteria fungi and viruses

* Information listed above is at the time of submission. *

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