SBIR Phase I: A versatile valveless mutlichannel parallel bioassay system

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$100,000.00
Award Year:
2008
Program:
SBIR
Phase:
Phase I
Contract:
0740847
Award Id:
88331
Agency Tracking Number:
0740847
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
535 W RESEARCH BLVD,, SUITE 135, M/S 300, FAYETTEVILLE, AR, 72701
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
125476825
Principal Investigator:
Xiao-LiSu
PhD
(479) 571-2592
xiaoli.su@biodetection-instruments.com
Business Contact:
Xiao-LiSu
PhD
(479) 571-2592
xiaoli.su@biodetection-instruments.com
Research Institute:
n/a
Abstract
This Small Business Innovation Research Phase I research project will develop a versatile high throughput bioassay system. The proposed system will be built on a patent-pending biosensing technology that has been exclusively licensed from the University of Arkansas. Using this technology, the company has obtained promising preliminary results for rapid and sensitive detection of food-borne pathogens, protein biomarkers, and pesticide residues. The Phase I research will focus on increasing sample throughput, reducing cross-contamination, and simplifying operation by developing a valveless mutichannel parallel bioassay system. The proposed system will consist of an automated sample/reagent delivery module, an easy-to-change multichannel biosensor cartridge, and an interface providing on-cartridge optical detection. Escherichia coli O157:H7, one of the most common and dangerous food-borne pathogens, will be used as the model target for the feasibility study. Microbial contamination of food products by pathogenic bacteria remains a major concern of our society. Food-borne illness affects millions of Americans each year and food producers are required to test their products for pathogens in a timely manner. Although conventional culture methods hypothetically allow the detection of a single cell of specific pathogens, they are extremely time-consuming, typically requiring at least 24 hours and complicated multi-steps to confirm the analysis. They also require laboratory setup and skilled personnel. The need of rapid detection of food pathogens and other important agents has posed a challenge for high throughput bioassays.

* information listed above is at the time of submission.

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