DEVELOPMENT OF A LONG-ACTING DISULFIRAM

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$354,273.00
Award Year:
1986
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
3337
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Bend Research Inc.
64550 Research Rd., Bend, OR, 97701
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Kelly L. Smith
Principal Investigator
(503) 382-4100
Business Contact:
() -
Research Institution:
n/a
Abstract
THE LONG-TERM OBJECTIVE OF THE PROPOSED PROGRAM IS TO DEVELOP A CONTROLLED-RELEASE DISULFIRAM IMPLANT FOR USE IN THE TREATMENT OF ALCOHOLISM. SPECIFIC PHASE I GOALS ARE 1. TO DESIGN CANDIDATE SYSTEMS, BASED ON TARGET PERFORMANCE TO BE DETERMINED FROM A REVIEW OF PRIOR RESEARCH, 2. TO PREPARE A SERIES OF CANDIDATE SYSTEMS, AND 3. TO DETERMINE THE IN VITRO DRUG RELEASE FROM THESE CANDIDATES. THE PROPOSED SYSTEM IS BASED ON A MEMBRANE-CONTROLLED BIOERODIBLE IMPLANT THAT WOULD DELIVER DISULFIRAM AT A CONSTANT RATE FOR SEVERAL WEEKS, RESULTING IN IMPROVED EFFICACY, GREATER PATIENT COMPLIANCE, AND FEWER SIDE EFFECTS THAN CURRENT THERAPY. SUCCESS IN THE PHASE I PROGRAM WOULD LEAD TO PROTOTYPE DEVELOPMENT, ANIMAL EFFICACY STUDIES, TOXICITY TESTING, AND FILING OF AN IND IN PHASE II FOR SUBSEQUENT HUMAN EFFICACY AND SAFETY STUDIES.

* information listed above is at the time of submission.

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