MEMBRANE-BASED PROCESS FOR SYNTHESIS OF CHIRAL PYRETHROID INSECTICIDES

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$239,272.00
Award Year:
1992
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
11741
Agency Tracking Number:
11741
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
64550 Research Rd, Bend, OR, 97701
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Paul Van Eikeren
Director Of Research
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
MANY PESTICIDES ARE CHIRAL--THAT IS, THEIR CHEMICAL STRUCTURES EXIST AS A PAIR OF "HANDED" STEREOISOMERS CALLED ENANTIOMERS. CHIRAL PESTICIDES GENERALLY EXHIBIT ENANTIOSELECTIVE ACTION, WHERE ONLY ONE ENANTIOMER IS ACTIVE AND EXHIBITS THE DESIRED BIOLOGICAL ACTIVITY. DESPITE MOUNTING EVIDENCE THAT CHIRAL PESTICIDES SHOULD OPTIMALLY BE DEVELOPED AND MARKETED AS SINGLE ENANTIOMERS, MORE THAN 90% OF SYNTHETIC CHIRAL PESTICIDES ARE MARKETED ASRACEMIC MIXTURES. THE PRINCIPAL REASON FOR THIS IS THE HIGHCOST AND TECHNICAL DIFFICULTY OF PREPARING CHIRAL PESTICIDES. MODERN SYNTHETIC PYRETHROID INSECTICIDES ARE AMONG THE MOST POTENT AND SELECTIVE PESTICIDES KNOWN. ALPHA-CYANO-3-PHENOXYBENZYL ALCOHOL, A CYANOHYDRIN PRODUCED BY THE REACTION OF HYDROGEN CYANIDE AND 3-PHENOXYBENZALDEHYDE, IS CHIRAL AND IS A MAJOR COMPONENT OF SEVERAL COMMERCIALLY IMPORTANT PESTICIDES. THIS PROJECT IS DIRECTED AT TESTING THE FEASIBILITY OF A NOVEL MEMBRANE-BASED ENZYME-REACTOR SYSTEM FOR THE PRODUCTION OF ENANTIOMERICALLY PURE (S)-ALPHA-CYANO-3-PHENOXYBENZYL ALCOHOL. THE PROPOSED SYSTEM IS READILY AMENABLE TO SCALEUP AND PROMISES TO PRODUCE ENANTIOMERICALLY PURE (S)-ALPHA-CYANO-3-PHENOXYBENZYL ALCOHOL AT LOW COST. THE TECHNICAL OBJECTIVES OF THE PHASE I PROJECT ARE 1) ESTABLISHA KNOWLEDGE BASE ON THE MEMBRANE-BASED PROCESS AND THE ENZYME-CATALYZED REACTION, 2) DESIGN AND CONSTRUCT A LABORATORY-SCALE SYSTEM ON THE BASIS OF THE KNOWLEDGE BASE, AND 3) MEASURE THE SYSTEM'S PERFORMANCE.

* information listed above is at the time of submission.

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