ENZYME REACTORS FOR THE SYNTHESIS OF PEPTIDE INHIBITORS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$744,961.00
Award Year:
1991
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
13919
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Bend Research Inc.
64550 Research Rd, Bend, OR, 97701
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
J Blair West
(503) 382-4100
Business Contact:
() -
Research Institution:
n/a
Abstract
HYPERTENSION IS ONE OF THE MAJOR HEALTH CHALLENGES FACING RESEARCHERS IN THE PHARMACEUTICAL FIELD. SYNTHETIC PEPTIDESTHAT ARE INHIBITORS OF RENIN AND ANGIOTENSIN-CONVERTING ENZYME HAVE PROVED VERY SUCCESSFUL IN TREATING HYPERTENSION AND HAVE SHOWN PROMISE IN TREATING OTHER DISEASES. WHILE THE DEMAND IS HIGH FOR SYNTHETIC PEPTIDES TO TREAT HYPERTENSION AND OTHER DISORDERS, AVAILABLE PEPTIDE-SYNTHESIS TECHNIQUES HAVE SERIOUS DRAWBACKS. THE DRAWBACKS INCLUDE RACEMIZATION OF COMPONENTS DURING COUPLINGREACTIONS, THE HIGH COST AND POTENTIAL ENVIRONMENTAL HAZARDS POSED BY THE COUPLING REAGENTS USED, AND THE EXPENSIVE AND TIME-CONSUMING PURIFICATION STEPS REQUIRED AFTER EACH COUPLING STEP. THIS PROJECT IS DIRECTED AT DEMONSTRATING THE FEASIBILITY OFAN IMPROVED PEPTIDE-SYNTHESIS PROCEDURE. THE PROCESS IS BASED ON A NOVEL MEMBRANE-BASED ENZYME REACTOR THAT OVERCOMES THE DISADVANTAGES OF CONVENTIONAL SYNTHESIS TECHNIQUES. THE OBJECTIVES OF THIS PHASE I PROGRAM ARE THREEFOLD: (1) TODETERMINE THE OPERATING CONDITIONS REQUIRED FOR A MEMBRANE-BASED ENZYME REACTOR FOR THE CONTINUOUS SYNTHESIS OF A MODEL PEPTIDE, (2) TO CONSTRUCT THE ENZYME REACTOR, AND(3) TO TEST THE PERFORMANCE OF THE SYSTEM. SUCCESS IN PHASE I WOULD LEAD TO A PHASE II PROGRAM FOCUSED ON THE OPTIMIZATION AND SCALE-UP OF THE PROPOSED PROCESS AND INVESTIGATION OF ADDITIONAL APPLICATIONS.

* information listed above is at the time of submission.

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