HOLLOW-FIBER DEVICE FOR REMOVING IL-1 IN HEMATOPOIESIS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$498,012.00
Award Year:
1992
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
13920
Agency Tracking Number:
13920
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
64550 Research Rd, Bend, OR, 97701
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Paul Van Eikeren
(503) 382-4100
Business Contact:
() -
Research Institute:
n/a
Abstract
ONE GOAL OF MEDICAL RESEARCH ON HEMATOPOIESIS-THE GROWTH AND DIFFERENTIATION OF PLURIPOTENT STEM CELLS WITHIN THE BONE MARROW-IS TO DUPLICATE THAT PROCESS IN VITRO FOR TREATMENT OF DISEASE. CURRENT METHODS ARE PLAGUED BY THE INHERENT COMPLEXITY OF THE PROCESS; FOR EXAMPLE, THE SAME GROWTH FACTORS THAT STIMULATE STEM-CELL GROWTH CAN ALSO STIMULATE UNWANTED DIFFERENTIATION. A METHOD THAT COULD REMOVE AND REPLACE SELECTED GROWTH FACTORS WOULD BE INVALUABLE TO THE PRACTICAL USE OF IN VITRO HEMATOPOIESIS. BEND RESEARCH, INC., PLANS TO DEVELOP A HOLLOW-FIBER MEMBRANE ADSORBENT (HFMA) THAT SELECTIVELY REMOVES HEMATOPOIETIC GROWTH FACTORS. IN PHASE I, THE FEASIBILITY OF THE CONCEPT WILL BE TESTED BY REMOVING INTERLEUKIN-1 (IL-1) FROM STEM-CELL CULTURE MEDIUM USING ANTIBODIES FOR IL-1 IMMOBILIZED IN THE PORES OF THE HOLLOW FIBERS. IN PHASE II, AN ENTIRE STEM-CELL CULTURE SYSTEM IN WHICH THE HFMAS WOULD CONTROL THE REMOVAL AND ADDITION OF SPECIFICGROWTH FACTORS WILL BE DEVELOPED. ULTIMATELY, THIS COULD LEAD TO COMMERCIALIZATION OF A SYSTEM FOR GROWING EITHER STEM CELLS OR SPECIFIC BLOOD-CELL LINEAGES FOR SUCH THERAPIES AS STEM-CELL REPLACEMENT IN CANCER TREATMENT OR TREATMENT OF IMMUNODEFICIENCY DISORDERS.

* information listed above is at the time of submission.

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