Injectable Microbeads for Delivery of Buprenorphine

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$99,999.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 DA09746-01,
Award Id:
29312
Agency Tracking Number:
29312
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
64550 Research Road, Bend, OR, 97701
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
James Nightingale
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
The objective of this research program is to demonstrate the feasibility of a new controlled-releasuse in an injectable formulation of buprenorphine to improve treatment of opioid dependence. The keytechnology is the use of bioerodible microporous microbeads with a controllable structure that allowas well as easily varied release rates and durations of release. These controlled-release microbeadsinjectable formulation that would result in much-improved patient compliance, better efficacy, and fthe case with current therapies. Specific tasks in Phase l include identification of bioerodible polcandidate microporous microbeads, in vitro testing of drug- loaded microbeads, determination of shorvivo evaluation of candidate microbeads in rhesus monkeys. The feasibility of this approach will bevitro and in vivo tests indicate efficacy over 3- to 14-day time periods. If this is the case, a Phaon further development of this technology and completion of preclinical studies necessary for submisInvestigational New Drug application.

* information listed above is at the time of submission.

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