AN IMMUNOASSAY FOR A HUMAN GROWTH HORMONE VARIANT

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$42,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
7186
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Berkeley Antibody Co
4131 Lakeside Drive Suite B, Richmond, CA, 94806
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
THOMAS R ANDERSON PHD
(415) 222-4940
Business Contact:
() -
Research Institution:
n/a
Abstract
THE OBJECTIVE OF THIS RESEARCH PROPOSAL IS TO DEVELOP ANTIBODIES CAPABLE OF DISTINGUISHING NORMAL HUMAN GROWTH HORMONE (HGH-N) FROM THE PRODUCT OF THE VARIANT GROWTH HORMONE GENE (HGH-V). PEPTIDES WILL BE SYNTHESIZED CORRESPONDING TO REGIONS OF DISSIMILARITY FROM BOTH FORMS OF THE HORMONE. THESE PEPTIDES WILL THEN BE CONJUGATED TO CARRIER MOLECULES FOR SYNTHESIS OF EFFECTIVE IMMUNOGENS AND USED TO GENERATE SPECIFIC ANTIBODIES IN RABBITS. THESE ANTIBODIES WILL BE TESTED FOR SPECIFICITY OF BINDING TO ONE FORM OF THE HORMONE OR THE OTHER. SUCH ANTIBODIES WILL BE USEFUL TO DETERMINE WHETHER OR NOT THE VARIANT GENE IS EXPRESSED IN HUMANS. IMMUNOASSAYS UTILIZING THESE HORMONES WILL HAVE EXTENSIVE UTILITY FOR THE DIAGNOSIS OF GROWTH DISORDERS IN HUMANS.

* information listed above is at the time of submission.

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