DEVELOPMENT OF AN AUTOIMMUNE DISEASE DIAGNOSTIC SYSTEM

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7903
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1988
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Bio Diagnostics Ltd
University City Science, 3624 Market St, Philadelphia, PA, 19104
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
NATIONAL INSTITUTE OF ARTHRITIS, DIABETES, AND DIGESTIVE AND KIDNEY DISEASE. SUMMARY PATIENTS WITH RHEUMATIC OR CONNECTIVE TISSUE DISEASE SUCH ASSYSTEMIC LUPUS ERYTHEMATOSUS, DIFFUSE SYSTEMIC SCLEROSIS, CREST SYNDROME, MIXED CONNECTIVE TISSUE DISEASE, RHEUMATOID ARTHRITIS, AND OTHER AUTOIMMUNE DISEASES PRODUCE ANTIBODIES AGAINST NUCLEAR ANTIGEN. MANY OF THESE ANTIBODIES ARE DIAGNOSTIC, AND OTHERS BY THEIR PRESENCE EXCLUDE SPECIFIC SIMILAR BUT NOT EASILY DISTINGUISHABLE DISEASE ENTITIES. THE MOLECULAR IDENTITIES OF ONLY THE MOST COMMON ANTIGENS HAVE BEEN DETERMINED AND SEVERAL DIFFERENT DIAGNOSTIC TESTS ARE AVAILABLE TO IDENTIFY THEM. THEY ARE SPECIFIC ONLY BY COMPARISON WITH REFERENCE SERA. WE WILL DEVELOP RECOMBINANTANTIGENS WITH DEFINED SERA FROM HUMAN CDNA-DERIVED EXPRESSION LIBRARIES. RECOMBINANT PROTEINS WITH THE RESPECTIVE EPITOPES WILL BE ASSEMBLED IN A DIAGNOSTIC KIT THAT ALLOWS UNAMBIGUOUS IDENTIFICATION OF THE ACTUAL ANTIGENIN A SINGLE SIMPLE IMMUNOBLOT TEST. THE TESTS WILL HAVE A SPECIFICITY NOT OBTAINABLE IN PRESENT DIAGNOSTIC LABORATORIES AND WILL BE CONSTRUCTED SO THAT IT IS EASILY READABLE EXCLUDING THE JUDGEMENTAL ANALYSIS PREVALENT IN PRESENT TECHNIQUES.

* information listed above is at the time of submission.

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