Separation Biosensor for Pharmacological Applications

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$693,470.00
Award Year:
1997
Program:
SBIR
Phase:
Phase II
Contract:
1 R43 GM52272-01,
Agency Tracking Number:
29451
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Bioanalytical Systems, Inc.
2701 Kent Avenue, West Lafayette, IN, 47906
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Peter Kissinger
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
The overall objective of this study is to develop a system that can be used to monitor pharmacokinepharmacological or neurochemical events in near real time. This will be accomplished by coupling micdirectly to capillary electrophoresis (CE). The system is much more versatile than conventional biossampling and analysis steps can be optimized separately. A system has been developed using CE with Lnm. In this proposal, an on-line derivatization system will be constructed in order to expand the apsystem for the analysis of primary amines. The development of a shunt probe for portal vein samplinginvestigated. Lastly, software will be written for near real-time plotting of the data. These threebasis of an instrument which is capable of monitoring and plotting blood levels of a drug in near reresolution of less than one minute. In Phase II, the system will be expanded to include an electrochfor tissue sampling will also be evaluated. This instrument should find wide applicability in the phbiomedical industries.

* information listed above is at the time of submission.

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