Lateral flow molecular assay for horse strangles

Award Information
Agency:
Department of Agriculture
Branch
n/a
Amount:
$80,000.00
Award Year:
2008
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
2008-00036
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
BIOHELIX CORP
32 TOZER RD, Beverly, MA, 01915
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
169510950
Principal Investigator:
Bertrand Lemieux
S. Director of Technology Development
(866) 800-5458
lemieux@biohelix.com
Business Contact:
Huimin Kong
CEO / President
(866) 800-5458
kong@biohelix.com
Research Institution:
n/a
Abstract
This proposal seeks to develop a simple, and sensitive molecular diagnostic assay for the detection of Streptococcus equi; the causative agent of strangles. Outbreaks of this disease at racetracks and training establishments caused major disruptions, and economic losses to owners, and trainers in the United States in recent years. The control of the spread of strangles relies on a combination of diagnostics, quarantine, vaccination, and in some cases on antibiotic therapy. A diagnostic test is needed to help veterinarians identify convalescent animals that are still infectious after clinical recovery because up to 10% of affected animals continue to shed Streptococcus equi sporadically for prolonged periods, after clinical signs have resolved. The ``gold standard'' for the detection of S. equi is culture of nasal swabs and washes. However, as nasal wash specimens often contain other beta hemolytic streptococci, like Streptococcus zooepidemicus, a diagnostic test must be highly specific. Molecular testing is highly specific. In addition, the assay proposed is easier to implement than other molecular testing technologies because it does not require costly instrumentation.

* information listed above is at the time of submission.

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