RAPID, ACCURATE IDENTIFICATION OF NON-FERMENTERS (NEGNB)

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 2903
Amount: $250,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Biolog, Inc.
3447 Investment Blvd. Suite #3, Hayward, CA, 94545
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Terri Marello
 Principal Investigator
 (415) 785-2564
Business Contact
Phone: () -
Research Institution
N/A
Abstract
APPROXIMATELY 15% OF BACTERIAL INFECTIONS ARE CAUSED BY NON-ENTEROBACTERIACEAE GRAM-NEGATIVE BACILLI. THIS IS AN EXTREMELY HETEROGENEOUS GROUP OF BACTERIA, AND PRESENT SPECIATION METHODS ARE VERY UNSATISFACTORY. BIOLOG HOLDS TWO PATENTS ON A NEW REDOX METHOD OF TESTING WHICH CAN BE DEVELOPED INTO IDENTIFICATION TESTS FOR ALL CLINICALLY IMPORTANT MICROORGANISMS. THESE TESTS WILL IDENTIFY AN ORGANISM BASED ON PATTERNS OF CARBON SOURCE UTILIZATION. THE METHOD EMPLOYS A TETRAZOLIUM DYE TO COLORIMETRICALLY INDICATE CARBON SOURCE OXIDATION. THIS PHASE I STUDY WILL DEMONSTRATE THE FEASIBILITY OF DEVELOPING A RAPID AND ACCURATE SPECIATION KIT FOR NON-ENTEROBACTERIACEAE GRAM-NEGATIVE 1.THE DEVELOPMENT OF A SUSPENSION MEDIUM COMPATIBLE WITH THE REDOX CHEMISTRY WHICH IS TAILORED TO THIS GROUP OF ORGANISMS, AND 2.A SURVEY OF APPROXIMATELY 200 ORGANIC CHEMICALS TO DEMONSTRATE BIOLOG'S TECHNOLOGY OFFERS MANY ADVANTAGES OVER PRESENT TECHNOLOGIES. THE PRINCIPAL ADVANTAGES ARE: 1.SPEED^FOR MOST MICROORGANISMS TESTS CAN BE COMPLETED IN 2 HOURS, 2.SIMPLICITY^THIS IS AN EASY-TO-INOCULATE AND READ SINGLE-COLOR METHOD, AND 3.ACCURACY^DRAWING FROM THOUSANDS OF POTENTIAL CARBON SOURCE UTILIZATION TESTS SHOULD ENABLE US TO DEVELOP TESTS THAT ARE MORE ACCURATE THAN ANY NOW AVAILABLE.

* information listed above is at the time of submission.

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