RAPID, ACCURATE IDENTIFICATION OF NON-FERMENTERS (NEGNB)

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$250,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
2903
Agency Tracking Number:
2903
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
3447 Investment Blvd. Suite #3, Hayward, CA, 94545
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Terri Marello
Principal Investigator
(415) 785-2564
Business Contact:
() -
Research Institute:
n/a
Abstract
APPROXIMATELY 15% OF BACTERIAL INFECTIONS ARE CAUSED BY NON-ENTEROBACTERIACEAE GRAM-NEGATIVE BACILLI. THIS IS AN EXTREMELY HETEROGENEOUS GROUP OF BACTERIA, AND PRESENT SPECIATION METHODS ARE VERY UNSATISFACTORY. BIOLOG HOLDS TWO PATENTS ON A NEW REDOX METHOD OF TESTING WHICH CAN BE DEVELOPED INTO IDENTIFICATION TESTS FOR ALL CLINICALLY IMPORTANT MICROORGANISMS. THESE TESTS WILL IDENTIFY AN ORGANISM BASED ON PATTERNS OF CARBON SOURCE UTILIZATION. THE METHOD EMPLOYS A TETRAZOLIUM DYE TO COLORIMETRICALLY INDICATE CARBON SOURCE OXIDATION. THIS PHASE I STUDY WILL DEMONSTRATE THE FEASIBILITY OF DEVELOPING A RAPID AND ACCURATE SPECIATION KIT FOR NON-ENTEROBACTERIACEAE GRAM-NEGATIVE 1.THE DEVELOPMENT OF A SUSPENSION MEDIUM COMPATIBLE WITH THE REDOX CHEMISTRY WHICH IS TAILORED TO THIS GROUP OF ORGANISMS, AND 2.A SURVEY OF APPROXIMATELY 200 ORGANIC CHEMICALS TO DEMONSTRATE BIOLOG'S TECHNOLOGY OFFERS MANY ADVANTAGES OVER PRESENT TECHNOLOGIES. THE PRINCIPAL ADVANTAGES ARE: 1.SPEED^FOR MOST MICROORGANISMS TESTS CAN BE COMPLETED IN 2 HOURS, 2.SIMPLICITY^THIS IS AN EASY-TO-INOCULATE AND READ SINGLE-COLOR METHOD, AND 3.ACCURACY^DRAWING FROM THOUSANDS OF POTENTIAL CARBON SOURCE UTILIZATION TESTS SHOULD ENABLE US TO DEVELOP TESTS THAT ARE MORE ACCURATE THAN ANY NOW AVAILABLE.

* information listed above is at the time of submission.

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