RAPID, ACCURATE IDENTIFICATION OF GRAM-POSITIVE ORGANISMS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
7085
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Biolog Inc
3447 Investment Blvd Suite 3, Hayward, CA, 94545
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
BARRY R. BOCHNER PHD
(415) 785-2564
Business Contact:
() -
Research Institution:
n/a
Abstract
GRAM-POSITIVE BACTERIA ARE RESPONSIBLE FOR A MAJOR PORTION OF BACTERIAL INFECTIONS. ALTHOUGH SOME SPECIES IN THIS GROUP ARE EASILY IDENTIFIED, BETTER GENERAL IDENTIFICATION METHODS ARE NEEDED. IT IS EXPECTED THAT BIOLOG, INC.'S NEW TECHNOLOGY WILL PERMIT IDENTIFICATION OF THE COMMONLY ADDRESSED GRAM-POSITIVE ORGANISMS AS WELL AS RAPID AND ACCURATE IDENTIFICATION OF LESS COMMON GRAM-POSITIVE BACTERIA THAT FREQUENTLY CAUSE SERIOUS INFECTION IN COMPROMISED HOSTS. EXISTING PRODUCTS CANNOT ADEQUATELY IDENTIFY THESE ORGANISMS. BIOLOG, INC. HOLDS TWO PATENTS ON A NEW REDOX METHOD OF TESTING THAT CAN BE DEVELOPED INTO IDENTIFICATION TESTS FOR ALL CLINICALLY IMPORTANT MICROORGANISMS. THESE TESTS WILL IDENTIFY AN ORGANISM BASED ON PATTERNS OF CARBON SOURCE UTILIZATION. THE METHOD EMPLOYS A TETRAZOLIUM DYE TO COLORIMETRICALLY INDICATE CARBON SOURCE OXIDATION. THIS PHASE I STUDY WILL DEMONSTRATE THE FEASIBILITY OF DEVELOPING A RAPID AND ACCURATE SPECIATION KIT FOR GRAM-POSITIVE BACTERIA. TWO TASKS ARE INVOLVED: (1) THE DEVELOPMENT OF A SUSPENSION MEDIUM COMPATIBLE WITH THE REDOX CHEMISTRY THAT IS TAILORED TO THIS GROUP OF ORGANISMS, AND (2) A SURVEY OF APPROXIMATELY 200 ORGANIC CHEMICALS TO DEMONSTRATE THAT NEW AND USEFUL SPECIATION TESTS CAN BE FOUND. BIOLOG, INC.'S TECHNOLOGY OFFERS MANY ADVANTAGES OVER PRESENT TECHNOLOGIES, INCLUDING SPEED, SIMPLICITY, AND ACCURACY.

* information listed above is at the time of submission.

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