MONITORING FISH VENTILATORY BEHAVIOR TO ASSESS BEHAVIORALLY AND NEURALLY MEDIATED EFFECTS OF CHEMICAL SUBSTANCES

Award Information
Agency:
National Science Foundation
Amount:
$245,220.00
Program:
SBIR
Contract:
N/A
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
1985
Phase:
Phase II
Agency Tracking Number:
689
Solicitation Topic Code:
N/A
Small Business Information
Biological Monitoring Inc.
P.o. Box 184, Blacksburg, VA, 24060
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 David Gruber
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
NORMAL VENTILATORY MOVEMENTS OF FISH GENERATE BIOELECTRIC POTENTIALS WHICH, WHEN PROPERLY AMPLIFIED AND FILTERED MAY BE INTERFACED TO COMPUTER BASED SYSTEMS TO FACILITATE AUTOMATED COLLECTION OF LARGE DATA BASES. WHEN FISH ARE EXPOSED TO ACUTELY AND SUBACUTELY TOXIC CONCENTRATIONS OF MANY CHEMICALS, COMMON VENTILATORY RESPONSES MAY INCLUDE CHANGES IN SIGNAL FREQUENCIES, AMPLITUDES, WAVEFORMS, AND COUGHS. TO BETTER UNDERSTAND THE MECHANISMS OF ACTION AND BEHAVIORALLY AND NEURALLY MEDIATED EFFECTS OF CHEMICAL SUBSTANCES ON FISH, THE AUTOMATION OF DATA COLLECTION IS ESSENTIAL. THE PROPOSED EFFORT ADDRESSES THIS ISSUE BY ATTEMPTING TO OVERCOME THE TECHNICAL DIFFICULTIES ASSOCIATEDWITH THIS PROBLEM. CHEMICALS WOULD BE CATEGORIZED BY THEIR STRUCTURE AND KNOWN TOXIC MECHANISMS OF ACTION TO DETERMINE THE MANNER IN WHICH EACH CATEGORY EFFETS FISH VENTILATORY BEHAVIOR.

* information listed above is at the time of submission.

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