MONITORING FISH VENTILATORY BEHAVIOR TO ASSESS BEHAVIORALLY AND NEURALLY MEDIATED EFFECTS OF CHEMICAL SUBSTANCES

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$245,220.00
Award Year:
1985
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
689
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Biological Monitoring Inc.
P.o. Box 184, Blacksburg, VA, 24060
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
David Gruber
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
NORMAL VENTILATORY MOVEMENTS OF FISH GENERATE BIOELECTRIC POTENTIALS WHICH, WHEN PROPERLY AMPLIFIED AND FILTERED MAY BE INTERFACED TO COMPUTER BASED SYSTEMS TO FACILITATE AUTOMATED COLLECTION OF LARGE DATA BASES. WHEN FISH ARE EXPOSED TO ACUTELY AND SUBACUTELY TOXIC CONCENTRATIONS OF MANY CHEMICALS, COMMON VENTILATORY RESPONSES MAY INCLUDE CHANGES IN SIGNAL FREQUENCIES, AMPLITUDES, WAVEFORMS, AND COUGHS. TO BETTER UNDERSTAND THE MECHANISMS OF ACTION AND BEHAVIORALLY AND NEURALLY MEDIATED EFFECTS OF CHEMICAL SUBSTANCES ON FISH, THE AUTOMATION OF DATA COLLECTION IS ESSENTIAL. THE PROPOSED EFFORT ADDRESSES THIS ISSUE BY ATTEMPTING TO OVERCOME THE TECHNICAL DIFFICULTIES ASSOCIATEDWITH THIS PROBLEM. CHEMICALS WOULD BE CATEGORIZED BY THEIR STRUCTURE AND KNOWN TOXIC MECHANISMS OF ACTION TO DETERMINE THE MANNER IN WHICH EACH CATEGORY EFFETS FISH VENTILATORY BEHAVIOR.

* information listed above is at the time of submission.

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