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DIFFERENTIATED CELLS AS TARGETS FOR CARCINOGEN-SCREENING

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 19221
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1992
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
10075-20 Tyler Place
Ijamsville, MD 21754
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 P Thomas Iype
 (301) 831-8810
Business Contact
Phone: () -
Research Institution
N/A
Abstract

THE OVERALL OBJECTIVE IS TO DEVELOP A NEW SYRIAN HAMSTER EMBRYO (SHE) MORPHOLOGICAL TRANSFORMATION ASSAY (MTA) EMPLOYING SPECIFIC CELL TYPES AS TARGETS AND USING DEFINED, SERUM-FREE CULTURE MEDIA. SPECIFIC AIMS FOR PHASE I STUDY INCLUDE: (1) ISOLATION AND CHARACTERIZATION OF SPECIFIC CELL TYPES (CHONDROCYTES, MYCOCYTES, FIBROBLASTS, ENDOTHELIAL CELLS) FROM SHE AS TARGETS FOR THE IN VITRO TRANSFORMATION ASSAY; (2) ADAPTATION OF EACH OF THE SELECTED TARGET CELL TYPES TO GROW IN APPROPRIATE SERUM-FREE GROWTH MEDIA; (3) DEVELOPMENT OF A PROTOTYPE SERUM-FREE MEDIUM THAT ENHANCES THE TRANSFORMED PHENOTYPE. TECHNICAL INNOVATION IN THIS PROJECT LIES IN THE SUBSTITUTION OF DEFINED FACTORS IN PLACE OF SERUM AND AVOIDANCE OF THE USE OF X-IRRADIATED "FEEDER" CELLS THAT MIGHT REPRESENT PREFERRED TARGETS FOR PARTICULAR CARCINOGENS WOULD CONSTITUTE AN IMPORTANT IMPROVEMENT OVER CURRENT MTAS. PROCEDURES AND REAGENTS DEVELOPED WILL BE USEFUL IN SCREENING ENVIRONMENTAL CHEMICALS FOR THEIR CARCINOGENIC POTENTIAL, HENCE COMMERCIALLY VALUABLE.

* Information listed above is at the time of submission. *

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