A TREATMENT OF HYDROPHILIC POLY(HYDROXYETHYL METHACRYLATE) CONTACT LENSES TO MINIMIZE IRREVERSIBLE PROTEIN ADSORPTION WILL BE TESTED.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3163
Agency Tracking Number:
3163
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
420 Chipeta Way, Suite 160, Salt Lake City, UT, 84108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DONALD E. GREGONIS
PRINCIPAL INVESTIGATOR
(801) 583-8444
Business Contact:
() -
Research Institute:
n/a
Abstract
A TREATMENT OF HYDROPHILIC POLY(HYDROXYETHYL METHACRYLATE) CONTACT LENSES TO MINIMIZE IRREVERSIBLE PROTEIN ADSORPTION WILL BE TESTED. PROTEIN ADSORPTION ON LENSES NOT ONLY LEADS TO CLOUDING AND OPACITIES, BUT ALSO INDUCES WHAT APPEARS TO BE AN IMMUNE RESPONSE IN THE WEARER. THIS RESPONSE IS OBSERVED IN THE EARLY STAGES TO INCLUDE INCREASED MUCUS PRODUCTION, MILD ITCHING, DECREASED LENS TOLERANCE AND DEVELOPMENT OF GIANT PAPILLAE IN THE UPPER TORSAL CONJUNCTION. LATER STAGES EXHIBIT A TOTAL LOSS OF LENS-WEARING TOLERANCE. THIS STUDY WILL BE DONE BOTH IN VITRO AND IN VIVO. THE IN VITRO STUDIES WILL MONITOR IRREVERSIBLE PROTEIN ADSORPTION ON THE CONTROL, AS WELL AS TREATED POLY(HYDROXYETHYL METHACRYLATE) SURFACE USING ARTIFICAL TEAR SOLUTION. TWO TECHNIQUES, ESCA (X-RAY PHOTOELECTRON SPECTROSCOPY) AND TIRIF (TOTAL INTERNAL REFLECTANCE INTRINSIC FLUORESCENCE) SPECTROSCOPY WILL BE USED IN PARALLEL TO MONITOR PROTEIN ADSORPTION TO THESE SURFACES. IN VIVO STUDIES WILL INCORPORATE A 10-DAY CONTINUOUS WEAR TEST UTILIZING THE RABBIT AS THE ANIMAL MODEL AND WILL BE DONE BOTH IN HOUSE AND THROUGH AN INDEPENDENT TESTING LAB. AGAIN, BOTH TREATED AND CONTROL LENSES WILL BE USED IN THIS STUDY. RETRIEVED LENSES WILL BE ANALYZED BY OPTICAL MICROSCOPY AND ESCA SPECTROSCOPY.

* information listed above is at the time of submission.

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