SINCE ANTIGENS RELEASED FROM TUMOR CELLS CAN THWART THE HOST'S IMMUNE REACTIVITY AGAINST IMMUNOGENIC TUMORS IN FAVOR OF TUMOR GROWTH, THE PRESENT WORK PROPOSES TO DEVELOP AN EXTRACORPOREAL SYSTEM TO REMOVE THE TUMOR ANTIGEN AS WELL AS THE BOUND ANTIGEN

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
2977
Agency Tracking Number:
2977
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P.o. Box 8852, Salt Lake City, UT, 84108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DONALD E. GREGONIS
PRINCIPAL INVESTIGATOR
(801) 583-8444
Business Contact:
() -
Research Institute:
n/a
Abstract
SINCE ANTIGENS RELEASED FROM TUMOR CELLS CAN THWART THE HOST'S IMMUNE REACTIVITY AGAINST IMMUNOGENIC TUMORS IN FAVOR OF TUMOR GROWTH, THE PRESENT WORK PROPOSES TO DEVELOP AN EXTRACORPOREAL SYSTEM TO REMOVE THE TUMOR ANTIGEN AS WELL AS THE BOUND ANTIGEN (ANTIGEN-ANTIBODY COMPLEX) FROM THE PATIENT'S PLASMA AND RETURN HIS/HER OWN PURIFIED PLASMA TO THE PATIENT. THE FIRST PHASE OF THE PROPOSED WORK INVOLVES IN VITRO STUDIES ON THE EFFICIENCY OF SEPARATION OF TUMOR ANTIGEN FROM THE PLASMA OF A BREAST CANCER PATIENT AND ITS EFFECT ON THE LYMPHOCYTE CYTOTOXICITY. THE PROCESS OF SEPARATION OF TUMOR ANTIGEN FROM PLASMA INVOLVES THREE STEPS: A.DISSOCIATION OF IMMUNE COMPLEXES AT PH 3.1 B.SEPARATION OF TUMOR ANTIGEN BY ULTRAFILTRATION. C.READJUSTMENT OF PLASMA PH BY DIALYSIS. IN VITRO STUDIES ARE PLANNED I.TO DESIGN AND DEVELOP THIS SYSTEM TO PROCESS THE PLASMA FROM A CANCER PATIENT, AND II.TO DETERMINE THE CHANGE IN LYMPHOCYTE CYTOTOXICITY

* information listed above is at the time of submission.

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