THE NEED FOR PATENT SMALL DIAMETER VASCULAR GRAFTS IS IMMEDIATE.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3219
Agency Tracking Number:
3219
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
65 Railroad Ave., Ridgefield, NJ, 07657
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
NANCY LARSEN
PRINCIPAL INVESTIGATOR
(201) 945-9550
Business Contact:
() -
Research Institute:
n/a
Abstract
THE NEED FOR PATENT SMALL DIAMETER VASCULAR GRAFTS IS IMMEDIATE. AT PRESENT THERE IS NO FDA-APPROVED SMALL VESSEL GRAFT OF 5MM OR SMALLER; SMALL DIAMETER (58MM) GRAFTS CURRENTLY IN USE (DACRON, EXPANDED POLYTETRAFLUOROETHYLENE (PTFE) TEFLON, AUTOLOGOUS SAPHENOUS VEIN, UMBILICAL VEIN BIOGRAFT) GENERALLY PERFORM POORLY. HYALURONIC ACID IS A NATURAL BIOPOLYMER AND AN UBIQUITOUS GLYCOSAMINOGLYCAN COMPONENT OF THE INTERCELLULAR MATRIX. THE EXTRAORDINARY TISSUE COMPATIBILITY OF SOLUBLE HYALURONIC ACID IS WELL DOCUMENTED. IN PHASE I OF THIS PROPOSED PROGRAM, INSOLUBLE HYALURONIC ACID COATINGS WILL BE STUDIED IN ORDER TO DETERMINE THEIR EFFECTIVENESS AS BIOLOGICAL INTERFACES WHICH ARE NONTHROMBOGENIC AND WHICH PROMOTE NORMAL HEALING (ENDOTHELIALIZATION). EXTENSIVE IN VITRO ENDOTHELIALIZATION TESTS IN TISSUE CULTURE INDICATE THAT, FOLLOWING TREATMENT WITH HYALURONIC ACID-CONTAINING MATERIAL, SYNTHETIC BIOMEDICAL POLYMERS, WHICH ORDINARILY WOULD NOT SUPPORT CELL GROWTH, NOW HAVE THE ABILITY TO PROMOTE APPARENTLY NORMAL ENDOTHELIAL CELL ATTACHMENT AND PROLIFERATION. RESULTS FROM PRELIMINARY IN VITRO TESTS OF BLOOD COMPATIBILITY (PARTIAL THROMBOPLASTIN TIMES, FACTOR XII ACTIVATION) STRONGLY SUGGEST THAT HYALURONIC ACID IS A SUPERIOR BLOOD COMPATIBLE MATERIAL. IN THESE TESTS, HYALURONIC ACID WAS COMPARED WITH OTHER WIDELY USED BLOOD CONTACTING MATERIALS. THE OBJECTIVE OF THIS PHASE I PROGRAM IS TO DEMONSTRATE MORE COMPLETELY THE UNIQUE BIOLOGICAL COMPATIBILITY OF HYALURONIC ACID AND ITS POTENTIAL FOR USE IN A SMALL DIAMETER VASCULAR GRAFT.

* information listed above is at the time of submission.

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