Tissue Sealant for Intracavitary Non-compressible Hemorrhage

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W31P4Q-08-C-0218
Agency Tracking Number: 07SB2-0064
Amount: $98,957.00
Phase: Phase I
Program: SBIR
Awards Year: 2008
Solicitation Year: 2007
Solicitation Topic Code: SB072-006
Solicitation Number: 2007.2
Small Business Information
BIOMEDICA MANAGEMENT CORP.
760 Parkside Avenue, Suite 210, Brooklyn, NY, 11226
DUNS: 146587345
HUBZone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 Weiliam Chen
 PI
 (631) 444-2788
 weiliam.chen@sunysb.edu
Business Contact
 George Falus
Title: President
Phone: (212) 719-4799
Email: gfalus@biomedic.net
Research Institution
N/A
Abstract
ClotFoam is a novel crosslinked polymer designed to stop hemorrhage without compression in severe wounds outside the operating room. ClotFoam’s ability to promote hemostasis in cases severe bleeding is based on the physical and coagulation properties of a fibrin sealant embedded in a gelatin support and enhanced by procoagulants, ions and molecules that increase the affinity to collagen. It is presented in 2 solutions that when mixed form a strong coating over lacerated tissue. CloFoam is delivered through a Veress needle, and distributed throughout the cavity in the form of a foam produced by a non-toxic foam inducer. Studies in rats and rabbits have shown that ClotFoam adheres to the abdominal cavity, even under profuse bleeding, initiating a rapid clot formation. Phase I proposed studies will provide the “proof of concept” for the use ClotFoam in cases of non-compressible hemorrhage by establishing its ability to adhere to lacerated tissue in a pool of blood using a rat aortic model. Phase II studies will establish the efficacy and safety in military relevant models (pigs) with induced intraperitoneal non-compressible hemorrhage secondary to grade IV/V traumatic liver damage. The study will evaluate restoration of vital functions and survival and achievement of hemostasis,

* information listed above is at the time of submission.

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