Tissue Sealant for Intracavitary Non-compressible Hemorrhage

Award Information
Agency:
Department of Defense
Branch
Defense Advanced Research Projects Agency
Amount:
$98,957.00
Award Year:
2008
Program:
SBIR
Phase:
Phase I
Contract:
W31P4Q-08-C-0218
Award Id:
86255
Agency Tracking Number:
07SB2-0064
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
760 Parkside Avenue, Suite 210, Brooklyn, NY, 11226
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
146587345
Principal Investigator:
Weiliam Chen
PI
(631) 444-2788
weiliam.chen@sunysb.edu
Business Contact:
George Falus
President
(212) 719-4799
gfalus@biomedic.net
Research Institute:
n/a
Abstract
ClotFoam is a novel crosslinked polymer designed to stop hemorrhage without compression in severe wounds outside the operating room. ClotFoam's ability to promote hemostasis in cases severe bleeding is based on the physical and coagulation properties of a fibrin sealant embedded in a gelatin support and enhanced by procoagulants, ions and molecules that increase the affinity to collagen. It is presented in 2 solutions that when mixed form a strong coating over lacerated tissue. CloFoam is delivered through a Veress needle, and distributed throughout the cavity in the form of a foam produced by a non-toxic foam inducer. Studies in rats and rabbits have shown that ClotFoam adheres to the abdominal cavity, even under profuse bleeding, initiating a rapid clot formation. Phase I proposed studies will provide the "proof of concept" for the use ClotFoam in cases of non-compressible hemorrhage by establishing its ability to adhere to lacerated tissue in a pool of blood using a rat aortic model. Phase II studies will establish the efficacy and safety in military relevant models (pigs) with induced intraperitoneal non-compressible hemorrhage secondary to grade IV/V traumatic liver damage. The study will evaluate restoration of vital functions and survival and achievement of hemostasis,

* information listed above is at the time of submission.

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