CULTURE DISHES WITH UNIQUE SURFACES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1990
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
8014
Agency Tracking Number:
8014
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1100 Nw Loop 410 Ste 360, San Antonio, TX, 78213
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
THE PURPOSE OF THIS RESEARCH IS TO FABRICATE AND TEST THE EFFICACY OF CULTURE DISHES WITH UNIQUE SURFACES. THIN FILMSOF METAL, METAL ALLOYS AND CERAMICS WILL BE APPLIED TO STANDARD POLYSTYRENE CULTURE DISHES. GROWTH OF FIBROBLAST AND OSTEOBLAST CELL LINES ON THE CULTURE PLATES WILL SERVE AS MODELS OF SOFT TISSUE AND HARD TISSUE MAMMALIAN CELLS. CELL MORPHOLOGY AND GROWTH WILL BE MONITORED BY PHASE CONTRAST MICROSCOPY. GROWTH CURVES WILL BE DETERMINED FOR BOTH CELL TYPES ON EACH CULTURE SURFACE. POLYSTYRENE PLATES, AS PROVIDED BY THE MANUFACTURER AND AFTER SHAM TREATMENT, WILL BE USED FOR CONTROLS. SURFACES WILL BE CHARACTERIZED BY X-RAY DIFFRACTION AND INFRARED SPECTROSCOPY. THE RESULTS OF THIS STUDY WILL INDICATE WHETHER FILMS PREPARED FROM METALS, METAL ALLOYS AND CERAMICS CAN BE USED AS UNIQUE SURFACES FOR MAMMALIAN CELL CULTURE. PHASE II RESEARCH WILL ESTABLISH SPECIFIC APPLICATIONS FOR INDIVIDUAL CULTURE DISH FABRICATIONS.

* information listed above is at the time of submission.

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