Dialysis Disinfectant Replacing Formaldehyde, Sterilants

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$600,000.00
Award Year:
1994
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
22186
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Biomedical Development
P. O. Box 6445, San Antonio, TX, 78209
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Richard W. Osgood
(512) 342-3898
Business Contact:
() -
Research Institution:
n/a
Abstract
Formaldehyde is a common disinfecting agent in dialyzer membrane reuse procedures. Since formaldehyde is carcinogenic, toxic and malodorous, any safe, cost-effective alternative would be a marketable an medical success. The long-term objective is to benefit patient care, employee safety, and cost effectiveness by establishing an economically competitive, non-toxic, market alternative to formaldehyde. The short-term objective is to test the effectiveness of a new cost-effective cold disinfectant technology for dialysis membranes following human use. A secondary objective is to evaluate the effect of this disinfecting process on maintaining fiber bundle volume (FBV). A clinically relevant Phase I study evaluating the effect of the cold disinfecting agent on dialyzer membranes will be performed. Biocidal effectiveness will be determined by culturing the dialyzer membranes following a typical 72-hour storage. A second in vitro protocol to evaluate FBV will also be done using dialysis membranes and plasma. The FBV data will be compared to previously obtained data from our unit as well as published observations on maintaining FBV. These protocols should provide relevant and sufficient data to thoroughly evaluate this cold sterilant and, if successful, provide sufficient preliminary work to substantiate a Phase II study.

* information listed above is at the time of submission.

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