NOVEL VEHICLE FOR TOPICAL DELIVERY OF CORTICOSTEROIDS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2002
Program:
STTR
Phase:
Phase I
Contract:
1R41AR049105-01
Award Id:
60621
Agency Tracking Number:
AR049105
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
BIOMEDICAL DEVELOPMENT CORP, 500 SANDAU, STE 200, SAN ANTONIO, TX, 78216
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
HRAWLS
(210) 308-0636
BDC@BIODEVCORP.COM
Business Contact:
GREGGSIEGEL
(210) 308-0636
GSIEGEL@BIODEVCORP.COM
Research Institute:
Univ of TX, Hlth Sciences Ctr at San Antonio

UT
SAN ANTONIO, TX, 78229

Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): Topical corticosteroids are useful treatment modalities for numerous dermatologic conditions. Most topical corticosteroids are applied in a cream or ointment vehicle, which require multiple applications, are subject to inadvertent removal, and can be cosmetically unacceptable. While efficacy has been shown to be increased with the use of hydrocolloid occlusive dressings, these dressings are often associated with local side effects and inherent cosmetic deficiencies. The goal of this project is to demonstrate the feasibility of using a novel coating technology as a topical delivery vehicle for corticosteroids that simultaneously serve as a semi-occlusive dressing. Coatings impregnated with corticosteroid will be formulated and tested to demonstrate efficacy in the vasoconstrictor assay in humans. PROPOSED COMMERCIAL APPLICATION: Topical corticosteroids are the most widely used preparations in dermatology. A novel vehicle that could improve efficacy and reduce treatments while being cost-effective would have significant commercial potential.

* information listed above is at the time of submission.

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