MACROMOLECULAR CONTRAST AGENTS FOR MAGNETIC RESONANCE

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$675,000.00
Award Year:
1994
Program:
SBIR
Phase:
Phase II
Contract:
N/A
Agency Tracking Number:
16440
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biomedical Frontiers, Inc.
1095 10th Avenue, Se, Minneapolis, MN, 55414
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 Hedlund, Bo E
 Principal Investigator
 (612) 378-0228
Business Contact
 1 R43 CA55452-01
Phone: () -
Research Institution
N/A
Abstract
BIOMEDICAL FRONTIERS (BMF) HAS ESTABLISHED THAT THE IRON CHELATOR, DEFEROXAMINE, CAN BE COVALENTLY BOUND TO POLYMERS AND HAS DEMONSTRATED, IN PRECLINICAL STUDIES, THAT THESE CONJUGATES CAN BE USED THERAPEUTICALLY AS ANTIOXIDANTS. WE WILL EVALUATE THESE COMPOUNDS, FOLLOWING SATURATION WITH FERRIC IRON, AS PARENTERAL MAGNETIC RESONANCE IMAGE (MRI) CONTRAST ENHANCERS. THE DIAGNOSTIC ACCURACY OF MRI IS GREATLY IMPROVED BY USING CONTRAST ENHANCERS. PRESENTLY USED, LOW MOLECULAR WEIGHT, CONTRAST ENHANCERS CONTAINING THE PARAMAGNETIC GADOLINIUM ION DIFFUSE RAPIDLY FROM THE VASCULAR COMPARTMENT INTO INTERSTITIAL FLUID AND ARE THEREFORE OF LIMITED UTILITY FOR A NUMBER OF IMAGING APPLICATIONS. A NON-TOXIC, MACROMOLECULAR CONTRAST AGENT, WILL IMPROVE RESOLUTION OF VASCULAR PATHOLOGY, PROVIDE INFORMATION ABOUT TISSUE PERFUSION AND MAY INCREASE THE DETECTION SENSITIVITY OF CERTAIN TYPES OF TUMORS. WE WILL, IN COLLABORATION WITH EXTERNAL CONSULTANTS, MEASURE RELAXIVITIES OF THREE CHELATOR-POLYMER CONJUGATES, DETERMINE THE DEGREE OF CONTRAST ENHANCEMENT AND ESTABLISH INITIAL SAFETY MARGINS IN ANIMALS. ASSUMING THAT THIS FEASIBILITY STUDY DEMONSTRATES THAT THESE COMPOUNDS ARE NON-TOXIC AND YIELD SIGNIFICANTLY ENHANCED IMAGE CONTRAST, WE WILL BE IN A POSITION TO DEVELOP A DIAGNOSTIC AGENT WITH A SUBSTANTIAL MARKET POTENTIAL.

* information listed above is at the time of submission.

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