NOVEL APPROACH TO THE PRODUCTION OF RECOMBINANT HUMAN CALCITONIN

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7987
Agency Tracking Number:
7987
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Box 2251, Princeton, NJ, 08543
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
CALCITONIN IS A HORMONE THAT STIMULATES THE INCORPORATION OF CALCIUM INTO BONE AND THUS ARRESTS BONE DETERIORATION PROCESSES SUCH AS POST-MENOPAUSAL OSTEOPOROSIS AND PAGET'S DISEASE. THE SYNTHETIC HORMONE CALCITONIN HAS BEEN SHOWN TO BE EFFECTIVE THERAPEUTICALLY IN ARRESTING PROGRESSIVE BONE LOSS IN THESE DISORDERS. AN ESTIMATED 24 MILLION AMERICAN WOMEN HAVE VARYING DEGREES OF OSTEOPOROSIS. PRESENTLY CALCITONIN WHICH IS PRODUCED BY SOLID PHASE PEPTIDE METHODS IS PROHIBITABLY EXPENSIVE (-$400/MG) FOR WIDESPREAD THERAPEUTIC USE. MOREOVER, THE APPLICATION OF DNA TECHNOLOGY TO THE PRODUCTION OF RELATIVELY SMALL HORMONES, SUCH AS CALCITONIN,A PEPTIDE WITH 32 AMINO ACIDS, PRESENTS SPECIAL PROBLEMS. IN THIS PROPOSAL WE PRESENT A NOVEL METHOD FOR THE HIGH YIELD PRODUCTION OF CALCITONIN USING RECOMBINANT DNA TECHNOLOGY.

* information listed above is at the time of submission.

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