ENZYME IMMUNOASSAY FOR EMERGENCY DRUG SCREEN

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$341,102.00
Award Year:
1984
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
547
Agency Tracking Number:
547
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
9932 West 74th Street, Eden Prairie, MN, 55344
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Peter H. Duquette
(612) 941-0080
Business Contact:
() -
Research Institute:
n/a
Abstract
DRUG ABUSE WITH ITS POTENTIAL FOR DRUG OVERDOSE POISONINGS, BOTH ACCIDENTAL AND INTENTIONAL, IS A MAJOR NATIONAL HEALTH PROBLEM WHICH IS RAPIDLY ON THE RISE. CONTRIBUTING FACTORS FOR THIS INCREASE ARE BOTH ECONOMIC (E.G., UNEMPLOYMENT) ANDMORE IMPORTANTLY FROM A LONG TERM STANDPOINT, THE RAPID INCREASE IN THE NUMBER OF PRESCRIPTIONS WRITTEN FOR DRUGS OF ABUSE (E.G., ANALGESICS AND PSYCHOPHARMACOLOGIC AGENTS) AND THE RAPID RISE IN THE NATIONAL GERIATRIC POPULATION. HEALTH CARE PROFESSIONALS HAVE RECOGNIZED FOR A LONG TIME THE NEED FOR RAPID ANALYTICAL METHODS FOR DETERMINING WHICH CLASS OF DRUG OR DRUGS ARE PRESENT IN AN EMERGENCY SITUATION. THE PUBLIC HEALTH SERVICE REALIZES THE SERIOUSNESS OF THIS PROBLEM AND HAS REQUESTED SMALL BUSINESSINNOVATIVE RESEARCH PROPOSALS UNDER THE AUSPICES OF THE ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION. NUMEROUS METHODS ARE AVAILABLE FOR DETERMINING DRUG LEVELS IN BIOLOGICAL FLUIDS BUT ALL MUST BE PERFORMED IN A LABORATORY ENVIRONMENT. MOST OF THE AVAILABLE ASSAYS REQUIRE EXPENSIVE EQUIPMENT, TRAINED PERSONNEL, AND ARE SLOWIN DETERMINING WHICH DRUG IS PRESENT. USE OF RADIOIMMUNOASSAY (RIA) PROCEDURES PRODUCES THE ADDITIONAL PROBLEM OF RADIOACTIVE WASTE DISPOSAL WHICH IS PRESENTLY, AND WILL INCREASINGLY BECOME A MAJOR PROBLEM IN THE FUTURE. WE PROPOSE TO DEVELOP A HOMOGENEOUS DIP STRIP ENZYME IMMUNOASSAY WHICH WILL BE USEFUL FOR EMERGENCY SITUATION DETERMINATION OF WHICH "CLASS" OF DRUG OR DRUGS WAS TAKEN IN OVERDOSE. THE ASSAY IS EXPECTED TO BE SIMPLE, FAST (LESS THAN 10 MINUTES), NONINSTRUMENTAL, AND THUS EASILY PORTABLE FOR USE BY EMERGENCY PERSONNEL AT THE SCENE OF THE SUSPECTED OVERDOSE. THIS PROCEDURE WILL DETERMINE WHICH DRUG CLASS IS PRESENT AND THUS ALLOW FOR GENERAL SUPPORTIVE MEASURES PRIOR TO ARRIVAL AT MEDICAL FACILITIES.

* information listed above is at the time of submission.

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