STABILIZATION OF PROTEINS BY CROSSLINKING

Award Information
Agency: Department of Defense
Branch: Army
Contract: N/A
Agency Tracking Number: 2338
Amount: $161,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1986
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
Bio-metric Systems Inc.
9932 W 74th St, Eden Prairie, MN, 55344
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Dr Melvin J Swanson
 (612) 941-0080
Business Contact
Phone: () -
Research Institution
N/A
Abstract
A PROJECT IS PROPOSED TO DEVELOP TECHNIQUES FOR STABILIZATION OF PROTEINS BY COVALENT CROSSLINKING. WE PLAN TO USE MONOCLONAL ANTIBODY SPECIFIC FOR T-2 TOXIN AS THE PRIMARY PROTEIN TO USE FOR DEVELOPING STABILIZATION TECHNOLOGY. USING LIGAND STABILIZATION TO DECREASE INACTIVATION DURING THE CROSSLINKING, WE PROPOSE TO EVALUATE THE EFFECTIVENESS OF INTRAMOLECULAR CROSSLINKING BETWEEN BOTH HYDROPHILIC AND HYDROPHOBIC GROUPS IN THE PROTEIN MOLECULES AS WELL AS INTERMOLECULAR CROSSLINKING WITH HIGHLY STRESS RESISTANT PROTEIN.

* information listed above is at the time of submission.

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