STABILIZATION OF PROTEINS BY CROSSLINKING

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$161,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
2338
Agency Tracking Number:
2338
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Bio-metric Systems Inc. (Currently SURMODICS, INC.)
9932 W 74th St, Eden Prairie, MN, 55344
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Melvin J Swanson
(612) 941-0080
Business Contact:
() -
Research Institution:
n/a
Abstract
A PROJECT IS PROPOSED TO DEVELOP TECHNIQUES FOR STABILIZATION OF PROTEINS BY COVALENT CROSSLINKING. WE PLAN TO USE MONOCLONAL ANTIBODY SPECIFIC FOR T-2 TOXIN AS THE PRIMARY PROTEIN TO USE FOR DEVELOPING STABILIZATION TECHNOLOGY. USING LIGAND STABILIZATION TO DECREASE INACTIVATION DURING THE CROSSLINKING, WE PROPOSE TO EVALUATE THE EFFECTIVENESS OF INTRAMOLECULAR CROSSLINKING BETWEEN BOTH HYDROPHILIC AND HYDROPHOBIC GROUPS IN THE PROTEIN MOLECULES AS WELL AS INTERMOLECULAR CROSSLINKING WITH HIGHLY STRESS RESISTANT PROTEIN.

* information listed above is at the time of submission.

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