IN VIVO TESTING OF AN IMPROVED VASCULAR PROSTHESIS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 8060
Amount: $497,064.00
Phase: Phase II
Program: SBIR
Awards Year: 1990
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Bio-metric Systems Inc.
9924 W 74th St, Eden Prairie, MN, 55344
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
NO ADEQUATE SMALL DIAMETER VASCULAR PROSTHESES ARE NOW COMMERCIALLY AVAILABLE, WITH THE MAJOR REASONS FOR LOSS OF PATENCY BEING THROMBUS FORMATION AND NEOINTIMAL FIBROUS HYPERPLASIA. ALSO, GRAFTS ARE OFTEN THE SITE OF CHRONIC INFECTIONS. THIS PROPOSED FEASIBILITY STUDY EXPECTS TO IMPROVE THE BIOCOMPATIBILITY OF COMMERCIALLY AVAILABLE VASCULAR IMPLANT POLYMERS BY SELECTIVELY IMMOBILIZING EXTRACELLULAR MATRIX PROTEINS AND GROWTH FACTORS TO PROMOTE ENDOTHELIAL CELL OVERGROWTH OF THE GRAFT LUMINAL SURFACE (TO PRODUCE SUPERIOR BLOOD COMPATIBILITY) AND SMOOTH MUSCLE GROWTH IN THE GRAFT MATRIX AND ON THE OUTER SURFACE (TO PRODUCE ADDED STRENGTH AND RESILIENCY). ANTIBIOTICS AND ANTITHROMBIC AGENTS WILL ALSO BE IMMOBILIZEDTO PREVENT THROMBUS FORMATION AND BACTERIAL GROWTH DURING THE PERIOD OF CELL OVERGROWTH. APPROPRIATE IN VITRO ASSAYS WILL BE CONDUCTED TO DETERMINE OPTIMUM CONCENTRATIONSTHAT SELECTIVELY PROMOTE ENDOTHELIAL OR SMOOTH MUSCLE OVERGROWTH, INHIBIT THROMBUS FORMATION, AND INHIBIT BACTERIAL GROWTH. A CONSORTIUM ARRANGEMENT HAS BEEN MADE TOCONDUCT PRELIMINARY IN VIVO IMPLANT STUDIES IN PHASE I AND EXTENSIVE IMPLANT STUDIES IN PHASE II. PROOF-OF-CONCEPT OF THIS TECHNOLOGY SHOULD ALLOW THE DEVELOPMENT OF VASCULAR IMPLANTS WITH IMPROVED BLOOD COMPATIBILITY AND REDUCED PROBLEMS WITH INFECTIONS.

* information listed above is at the time of submission.

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