STABILIZATION OF ENZYMES FOR BIOREACTORS

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$49,030.00
Award Year:
1989
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
10763
Agency Tracking Number:
10763
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
9924 W 74th St, Eden Prairie, MN, 55344
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Melvin J Swanson
Principal Investigator
(612) 829-2700
Business Contact:
() -
Research Institution:
n/a
Abstract
A PROJECT IS PROPOSED TO DEVELOP NEW STABILIZATION TECHNIQUES FOR IMMOBILIZED ENZYMES USED IN BIOREACTORS. THIS TECHNIQUE, WHICH HAS BEEN DEMONSTRATED TO SIGNIFICANTLYSTABILIZE AN ENZYME TO STORAGE AT ELEVATED TEMPERATURES, WILL BE FURTHER DEVELOPED AND APPLIED TO STABILIZATION OF FUNCTIONING IMMOBILIZED ENZYMES AS USED IN BIOREACTORS. THE RATIONALE IS TO PROVIDE AN ENVIRONMENT FOR OPTIMAL STABILITY SURROUNDING THE ENZME, THEN TO BIND IT TOGETHER BY COPOLYMERIZATION TO OBTAIN A VERY LARGE MOLECULAR WEIGHT,BUT SOLUBLE ENZYME DERIVATIVE. THE CROSSLINKED ENZYME WILL THEN BE IMMOBILIZED AND TESTED FOR STABILITY. THE ENZYME TOBE STABILIZED IN THIS MANNER DURING THE PHASE I PROJECT IS BETA-GALACTOSIDASE (LACTASE), WHICH IS USED IN BIOREACTORS TO HYDROLYZE LACTOSE IN MILK OR WHEY TO EITHER MAKE DAIRY PRODUCTS USABLE BY PEOPLE WITH LACTOSE INTOLERANCE OR TO MAKE A WASTE PRODUCT OF THE CHEESE INDUSTRY INTO A USEFUL PRODUCT. THE GOAL OF THE PHASE I PROJECT IS TO DOUBLE THE OVERALL USE LIFE (TOTAL HYDROLYSIS CAPACITY) OF IMMOBILIZED LACTASE BY THIS STABILIZATION TECHNIQUE.

* information listed above is at the time of submission.

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