CONDUCTANCE BIOSENSOR FOR DETECTING MICROORGANISMS

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$54,397.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
15731
Agency Tracking Number:
15731
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
9924 W Seventy-fourth St, Eden Prairie, MN, 55344
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Melvin J Swanson
Principal Investigator
(612) 829-2710
Business Contact:
() -
Research Institute:
n/a
Abstract
A PROJECT IS PROPOSED TO DEVELOP A BIOSENSOR FOR MEASURING PATHOGENIC MICROORGANISMS IN WATER BY MEASURING CHANGES IN CONDUCTANCE ACROSS MICROPOROUS, POLYCARBONATE MEMBRANE COATE WITH SPECIFIC ANTIBODIES. THE MEMBRANES WILL BE COATED WITH HYDROPHILIC POLYMERS USING PHOTOCHEMICAL COUPLING. ANTIBODIES SPECIFIC FOR THE ANALYTE WILL THEN BE COUPLED TO THE POLYMER-COATED MEMBRANES PRIMARILY IN THE PORES. THE COATING AND IMMOBILIZATION METHODS ARE DESIGNED TO MINIMIZE NONSPECIFIC ADSORPTION OF PROTEINS AND TO STABILIZE THE ANTIBODY. THE PURPOSE IS TO DEMONSTRATE THAT THIS TECHNIQUE CAN BE USED TO RAPIDLY AND SENSITIVELY DETECT MICROBIAL AGENTS IN CLINICAL SAMPLES. THIS TECHNIQUE WILL FIRST BE DEVELOPED FOR DETECTING E. COLI IN WATER SAMPLES.

* information listed above is at the time of submission.

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