CONDUCTANCE BIOSENSOR FOR DETECTING MICROORGANISMS

Award Information
Agency: Department of Defense
Branch: Army
Contract: N/A
Agency Tracking Number: 15731
Amount: $54,397.00
Phase: Phase I
Program: SBIR
Awards Year: 1991
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
9924 W Seventy-fourth St, Eden Prairie, MN, 55344
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Dr Melvin J Swanson
 Principal Investigator
 (612) 829-2710
Business Contact
Phone: () -
Research Institution
N/A
Abstract
A PROJECT IS PROPOSED TO DEVELOP A BIOSENSOR FOR MEASURING PATHOGENIC MICROORGANISMS IN WATER BY MEASURING CHANGES IN CONDUCTANCE ACROSS MICROPOROUS, POLYCARBONATE MEMBRANE COATE WITH SPECIFIC ANTIBODIES. THE MEMBRANES WILL BE COATED WITH HYDROPHILIC POLYMERS USING PHOTOCHEMICAL COUPLING. ANTIBODIES SPECIFIC FOR THE ANALYTE WILL THEN BE COUPLED TO THE POLYMER-COATED MEMBRANES PRIMARILY IN THE PORES. THE COATING AND IMMOBILIZATION METHODS ARE DESIGNED TO MINIMIZE NONSPECIFIC ADSORPTION OF PROTEINS AND TO STABILIZE THE ANTIBODY. THE PURPOSE IS TO DEMONSTRATE THAT THIS TECHNIQUE CAN BE USED TO RAPIDLY AND SENSITIVELY DETECT MICROBIAL AGENTS IN CLINICAL SAMPLES. THIS TECHNIQUE WILL FIRST BE DEVELOPED FOR DETECTING E. COLI IN WATER SAMPLES.

* Information listed above is at the time of submission. *

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