SURFACE MODIFICATION TO IMPROVE BREAST PROSTHESES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
18997
Agency Tracking Number:
18997
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
9924 West 74th Street, Eden Prairie, MN, 55344
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
David L Clapper
(612) 829-2700
Business Contact:
() -
Research Institute:
n/a
Abstract
THE MOST COMMON PROBLEM WITH CURRENT BREAST PROSTHESES IS THE DEVELOPMENT OF A CONTRACTILE FIBROUS CAPSULE. CAPSULAR CONTRACTURE PRODUCES BREAST HARDINING, PAIN, AND DISTORTION OF THE BREAST SHAPE. THIS PHASE I PROJECT WILL COMBINE TWO TYPES OF PROSTHESIS SURFACE MODIFICATIONS TO REDUCE CAPSULE FORMATION AND CONTRACTURE. FIRST, THE PROSTHESIS TO BE USED WILL HAVE A TEXTURE (POROUS) SILICONE RUBBER SURFACE. POROUS POLYMERS ARE REPORTED TO IMPROVE TISSUE INTEGRATION, DECREASE THE SIZE OF FIBROUS CAPSULES FORMED, AND INHIBIT THE ORDERED FORMATION OF COLLAGEN/MYOFIBRIL LAYERS THAT ARE TYPICAL OF CONTRACTED CAPSULES. SECOND, THE TEXTURED SURFACE WILL BE COATED WITH EXTRACELLULAR MATRIX (ECM) PROTEINS AND/OR PEPTIDES TO FURTHER IMPROVE TISSUE INTEGRATION BY PROMOTING THE ATTACHMENT AND INGROWTH OF BREAST TISSUE. RADIOLABELLED ECM PROTEINS AND PEPTIDES WILL BE USED TO OPTIMIZE IMMOBILIZATION EFFICIENCY ON THE PROSTHESES, AND THEIR BIOACTIVITY WILL BE EVALUATED IN VITRO BY QUANTITATING THE ATTACHMENT AND GROWTH OF FIBROBLASTS AND EPITHELIAL CELLS. COATED PROSTHESES WILL BE IMPLANTED SUBCUTANEOUSLY INTO PIGS AND HISTOLOGICALLY EVALUATED FOR TISSUE INTEGRATION AND FIBROUS ENCAPSULATION. MAMMARY PROSTEHESES ARE THE MOST COMMONLY USED SYNTHETIC IMPLANTS IN THE UNITED STATES, AND ABOUT 30% OF THESE PROSTHESES ENCOUNTER SIGNIFICANT PROBLEMS WITH CAPSULAR CONTRACTURE. THEREFORE, PROSTHESES MODIFICATIONS THATREDUCE THE INCIDENCE OF THIS PROBLEM WOULD BE EXTREMELY BENEFICIAL.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government