Immobilized Fatty Acids for Reversible Albumin Binding

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 HL50224-1A1,
Agency Tracking Number: 25140
Amount: $735,599.00
Phase: Phase II
Program: SBIR
Awards Year: 1996
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
9924 W 74th Street, Eden Prairie, MN, 55344
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Peter Duquette
 (612) 829-2700
Business Contact
Phone: () -
Research Institution
We will evaluate four photoactivatable fatty acid analogs and three photoactivatable C16 alkylchain derivatives for their ability to derivatize to four representative biomaterials and subsequently adsorbhuman albumin. The research lists four Specific Aims. First, four photoactivatable fatty acid analogsand three photoactivatable C16 alkyl chain derivatives will be chemically synthesized. Second, eachof the above compounds will be evaluated on four biomaterials including silicon rubber, polyurethane,polyethylene and polyvinyl chloride with respect to their loading densities on these biomaterials. Thenext Specific Aim will address the albumin adsorptive properties of each of the above coatedbiomaterials in comparison to non-derivatized biomaterials. Finally, each of the derivatized biomaterialswill be examined for their abilities to (1) adsorb plasma proteins, (2) adhere platelets, and (3) supportplatelet activation. These latter studies will shed light on whether both ionic and hydrophobic groupsare necessary for the observed increase in albumin binding and whether the increase in albumin bindingis due, in part, to the use of a hydrophilic polyethylene glycol spacer.

* Information listed above is at the time of submission. *

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