Latex Coating to Prevent Allergen Leaching

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 22345
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1993
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
9924 West 74th Street, Eden Prairie, MN, 55344
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Melvin J. Swanson
 (612) 829-2700
Business Contact
Phone: () -
Research Institution
A project is proposed to develop reagents and methods for coating latex rubber devices to prevent leaching of allergenic proteins. Allergies to latex rubber proteins has become recognized as a serious problem in recent years. These allergic problems are partly due to increased exposure by medical personnel and patients resulting from increased use of latex gloves for protection from exposure to the AIDS virus and other infectious agents. Using hydrophilic photoreactive polymers that have been developed for use in preventing adsorption of proteins from solution onto surfaces, preliminary evidence has been obtained that leaching of latex allergens can be dramatically reduced (more than 90%) by coating the surface with such a polymer. This proposed project will focus on further development of reagents and coating methods to achieve maximum reduction of allergen leaching from latex. Photopolymers will be synthesized having various molecular weights, levels of photogroups and compositions. Both glove material and other latex products will be coated and then tested for extractable protein allergens by protein assays, electrophoresis, and immunoblotting methods. The goal is to reduce leaching of allergenic proteins to undetectable levels. A secondary goal is to achieve lubricity appropriate for the applications (i. e., donning lubricity without powder for gloves and wet lubricity for catheter applications) in addition to preventing protein leaching.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government