Polysulfonate Immobilization for Thrombus Prevention

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 22315
Amount: $49,987.00
Phase: Phase I
Program: SBIR
Awards Year: 1993
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Bio-metric Systems, Inc.
9924 West 74th Street, Eden Prairie, MN, 55344
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Peter H. Duquette
 (612) 829-2700
Business Contact
Phone: () -
Research Institution
N/A
Abstract
All synthetic materials which contact blood are thrombogenic and activate processes such as fibrin coagulation, platelet adhesion, and complement activation. Numerous investigations have been conducted to develop nonthrombogenic materials because of these observations. These include chemical modifications of the natural surface by the addition of hydrophilic moieties or immobilization of biologically active substrates. An alternative approach would be to incorporate anionic moieties into the polymer matrix, which is reported to result in a highly antithrombogenic surface. The goal of this Phase I research project is to utilize BSI's proprietary photoimmobiliz- ation technology to covalently immobilize photoreactive polyacrylamide-polysulfonate polymers onto various biomaterials. These polysulfonate coatings will potentially affect protein and platelet adhesion and lead to the development of long-lasting antithrombogenic surfaces.

* information listed above is at the time of submission.

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