Vascular Graft Coating for Transmural Endothelialization

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 HL54413-01,
Award Id:
29546
Agency Tracking Number:
29546
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
9924 W 74th Street, Eden Prairie, MN, 55344
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
David Clapper
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
There are currently no artificial polymeric vascular grafts with an internal diameter of less thanadequate long-term patency, with occlusion being due to a combination of thrombus formation and intiproject will improve the patency of such grafts by promoting rapid and stable transmural endothelialendothelialization process, capillaries from surrounding tissue invade the wall porosity of grafts acells (EC's) which colonize the graft lumen at multiple points along its length. If the resultant enand exhibits a sufficiently normal physiology, it would maintain graft patency by inhibiting both thintimal hyperplasia. Expanded polytetrafluoroethylene (ePTFE) grafts with an internodal distance ofto provide a wall porosity that is sufficient to allow capillary ingrowth, and ECM proteins and peptimmobilized into the graft porosity to actively stimulate capillary ingrowth. During Phase I, 3 protbe photoimmobilized onto ePTFE grafts and evaluated: 1) in vitro for attachment, migration, and prolendothelial cells and 2) in vivo for capillary ingrowth and transmural endothelialization.

* information listed above is at the time of submission.

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