Surface Modification to Improve Osseous Integration

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 AR41612-01A4,
Award Id:
29156
Agency Tracking Number:
29156
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Bsi Corp. (Currently SURMODICS, INC.)
9924 W 74th Street, Eden Prairie, MN, 55344
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
David Clapper
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
We will improve the fixation of non-cemented titanium hip prostheses by coating the porous surfacescollagens and growth factors. Two collagens (types I and IV) will be covalently coupled to the implapatented BSI photochemistry, and two growth factors will be non- covalently incorporated into each cmanner that slowly releases the GF's over several days. The collagen/GF coatings are expected to imposteoblasts into the porous surface of the implants, thus, 1) reducing the time required for implantextent of bone ingrowth into the porous region, and 3) increasing the effective life of the implantloosening. During the Phase I in vitro studies, each collagen type will be photoimmobilized onto CPporous CP titanium disks, with tritium-labelled collagens being used to quantitate loading levels. Eincorporated into each collagen coating and the combinations will be evaluated for osteoblast attachexpression of differentiated characteristics. Finally, coatings that demonstrate superior in vitro papplied to porous- surface titanium implants, 2) implanted in a rabbit metaphyseal model, and 3) evastrength of bonding to bone and histologically for inflammation and tissue ingrowth.

* information listed above is at the time of submission.

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