THE GOAL OF THIS RESEARCH IS TO DEVELOP A HIGHLY SENSITIVE AND SPECIFIC RADIOIMMUNOASSAY FOR LEUKOTRIENE E4 AND LEUKOTRIENE E4-N-ACETATE, TWO IMPORTANT METABOLITES OF LEUKOTRIENE C4 AND D4.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4965
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Front & Lloyd Streets, Chester, PA, 19013
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 ROBERT E ZIPKIN
 PRINCIPAL INVESTIGATOR
 (215) 874-1433
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE GOAL OF THIS RESEARCH IS TO DEVELOP A HIGHLY SENSITIVE AND SPECIFIC RADIOIMMUNOASSAY FOR LEUKOTRIENE E4 AND LEUKOTRIENE E4-N-ACETATE, TWO IMPORTANT METABOLITES OF LEUKOTRIENE C4 AND D4. THESE LEUKOTRIENES ARE POTENT BRONCO- AND CORONARY ARTERY VASOCONSTRICTORS, INCREASE VASCULAR PERMEABILITY, STIMULATE MUCUS SECRETION, AND CAUSE LONG-LASTING HYPOTENSION, THUS PLAYING A PATHOPHYSIOLOGICAL ROLE IN IMMEDIATE HYPERSENSITIVITY REACTIONS, INFLAMMATION, AND TISSUE TRAUMA. SPECIFIC AIMS OF THIS PROJECT INCLUDE: (1) PREPARATION OF A NUMBER OF LEUKOTRIENE E4 AND LEUKOTRI- ENE E4-N-AC-PROTEIN CONJUGATES HAVING VARIOUS MODES OF LEUKOTRIENE TO PROTEIN LINKAGE; (2) PRODUCTION OF ANTIBODIESTO EACH CONJUGATE BY IMMUNIZATION OF RABBITS; (3) COMPARISONOF THE ANTIBODIES AND SELECTION OF THOSE WITH HIGHEST SPECIFICITY AND SENSITIVITY; AND (4) PRODUCTION OF LEUKOTRIENE E4 AND E4-N-AC RADIOIMMUNOASSAY KITS FOR COMMERCIALIZATION. A LARGE NUMBER OF PHARMACEUTICAL COMPANIES ARE DEVELOPING SPECIFIC THERAPEUTIC AGENTS BASED ON LEUKOTRIENE INHIBITION AND/OR ANTAGONISM, AND THESE KITS ARE EXPECTED TO FIND WIDE APPLICATION.

* Information listed above is at the time of submission. *

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