RADIO IMMUNOASSAY KITS FOR PLATELET ACTIVATING FACTOR

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 8052
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1988
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
5166 Campus Dr, Plymouth Meeting, PA, 19462
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE GOAL OF THE PROPOSED RESEARCH IS TO DEVELOP A HIGHLY SENSITIVE AND SPECIFIC RADIOIMMUNOASSAY FOR PLATELET ACTIVATING FACTOR (PAF). PAF IS A LIPID MEDIATOR PRODUCED BY A VARIETY OF INFLAMMATORY CELLS SUCH AS NEUTROPHILS, PLATELETS, MACROPHAGES, EOSINOPHILS, AND VASCULAR ENDOTHELIAL CELLS. PAF INDUCES A NUMBER OF IN VIVO EFFECTS INCLUDING ACUTE BRONCHOCONSTRICTION AND BRONCHOPULMONARY HYPERREAC-TIVITY ACCOMPANIED BY PLATELET, EOSINOPHIL, AND MACROPHAGE ACTIVATION AND RECRUITMENT. THUS THE ROLE OF PAFIN THE PATHOPHYSIOLOGY OF IMMEDIATE HYPERSENSITIVITY REACTIONS, ESPECIALLY ASTHMA, AND INFLAMMATION IS APPARENT. SPECIFIC AIMS INCLUDE: 1) PREPARATION OF A METABOLICALLY STABLE PAF DERIVATIVE SUITABLY FUNCTIONALIZED FOR PROTEIN CONJUGATION, 2) PREPARATION OF A PAF-PROTEIN CONJUGATE. 3) PRODUCTION OF ANTIBODIES TO THE CONJUGATE BY IMMUNIZATION OF RABBITS, 4) PRODUCTION OF PAF RADIOIMMUNOASSAY KITS FOR COMMERCIAL-IZATION. A LARGE NUMBER OF PHARMACEUTICAL COMPANIES ARE DEVELOPING NOVEL AND MORE SPECIFIC THERAPEUTIC AGENTS BASED ON PAF INHIBITION OR ANTAGONISM AND THESE KITS ARE EXPECTED TO FIND WIDE APPLICATION.

* Information listed above is at the time of submission. *

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