CONSIDERABLE EFFORT HAS BEEN FOCUSED ON THE USE OF CYANOA- CRYLATES FOR CLINICAL OCULAR REPAIR AS ADJUNCTS TO OR IN LIEU OF SURGICAL PROCEDURES.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4916
Amount: $48,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
309 Farmington Avenue, Farmington, CT, 06032
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 PAUL T PICCIANO
 PRINCIPAL INVESTIGATOR
 (203) 674-1444
Business Contact
Phone: () -
Research Institution
N/A
Abstract
CONSIDERABLE EFFORT HAS BEEN FOCUSED ON THE USE OF CYANOA- CRYLATES FOR CLINICAL OCULAR REPAIR AS ADJUNCTS TO OR IN LIEU OF SURGICAL PROCEDURES. THROUGH REPEATED STUDIES, HOWEVER, THESE ADHESIVES HAVE PROVED TO BE DAMAGING TO THE EYE TISSUE BY CAUSING INFLAMMATION, NEOVASCULARIZATION AND TISSUE NECROSIS. AS AN ALTERNATIVE TO CYANOACRYLATES, THIS PROJECT PROPOSES THE USE OF MUSSEL-ADHESIVE PROTEIN (MAP) ASA TISSUE ADHESIVE IN OCULAR REPAIR. EXPERIMENTS WILL BE CONDUCTED WITH MAP ON RETINAL AND CORNEAL TISSUE IN VITRO AND IN SITU; MAP WILL ALSO BE EVALUATED FOR STRENGTH AND DURATION OF TISSUE BONDING. MAP IS A STRONG ADHESIVE CEMENTAND, UNLIKE CYANOACRYLATES, APPEARS TO BE BIOCOMPATIBLE; IT WILL LIKELY BECOME AN ATTRACTIVE ALTERNATIVE FOR THE TREATMENT OF OCULAR INJURIES.

* Information listed above is at the time of submission. *

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