Multiple Indication Adjuvants

Award Information
Agency:
Department of Defense
Branch
Office for Chemical and Biological Defense
Amount:
$69,990.00
Award Year:
2008
Program:
SBIR
Phase:
Phase I
Contract:
W911NF-08-C-0044
Award Id:
86062
Agency Tracking Number:
C081-105-0080
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2901 South Loop Drive, Suite 3360, Ames, IA, 50010
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
606727076
Principal Investigator:
Ramon Flick
Senior Director of Vaccine Developm
(515) 296-3944
rflick@bpsys.net
Business Contact:
Carl Langren
Chief Financial Officer
(515) 309-0138
clangren@bpsys.net
Research Institution:
n/a
Abstract
The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift Valley fever virus (RVFV, bunyavirus), and Lassa virus (LV, arenavirus), to evaluate the adjuvant potency of the alphaGal Adjuvant Technology. This technology is based on the innate naturally acquired human immune response to galactose alpha(1,3)galactose alpha(1,4)N-acetylglucosamine (alphaGal) epitopes. In Phase I we will illustrate the broad application of the alphaGal Adjuvant Technology to antiviral vaccines by demonstrating that alphaGal-modification significantly enhances and modulates the immune response to select vaccines in a mouse model. In the Phase I Option, the optimized adjuvant conditions eliciting the best immune response to the different tested antiviral vaccines, based upon the mouse model immunological data, will be utilized in limited lethal challenge efficacy experiments to be conducted with wild-type virus under Biosafety Level (BSL)-4 conditions in the mouse model. Significant efficacy will lead to a Phase II proposal and further studies involving adjuvant efficacy in small rodents and non-human primates.

* information listed above is at the time of submission.

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