Novel Repeat Elements for Genome Analysis

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$96,792.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 CA71315-01,
Award Id:
29275
Agency Tracking Number:
29275
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
5 Science Park, New Haven, CT, 06511
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Wan-Liang Li
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
The goal of this Phase I project is to isolate and characterize new chromosome-specific human repetelements. The resulting probes will be valuable for cytogenetic cancer diagnostics. Our preliminaryrandom amplification of polymorphic DNA (RAPD) is a valuable approach for the discovery of chromosompolymorphic repetitive DNA elements. Phase I will involve systematic and high- throughput employmentgenome-wide search for such elements. The repetitive DNAs will be cloned, then characterized by sequchromosomal localization and sublocalization, heterozygosity determination, evaluation of evolutionadetermination of average copy number. Additionally, Phase I will include modeling cytogenetic analyschromosomal aberrations using chromosome-specific repetitive DNA probes. Our model system will emplorepetitive element mapping to chromosome 20q12, which we discovered in preliminary research using RAprobe in interphase nuclei representing specific hematological malignancies known to have chromosomavicinity

* information listed above is at the time of submission.

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