Novel Repeat Elements for Genome Analysis

Award Information

Agency: Department of Health and Human Services

Branch: N/A

Contract: 1 R43 CA71315-01,

Agency Tracking Number: 29275

Amount: $96,792.00

Phase: Phase I

Program: SBIR

Solicitation Topic Code: N/A

Solicitation Number: N/A

Timeline

Solicitation Year: N/A

Award Year: 1995

Award Start Date (Proposal Award Date): N/A

Award End Date (Contract End Date): N/A

Small Business Information

Genaissance Pharmaceuticals

5 Science Park

New Haven, CT 06511

United States

DUNS: N/A

HUBZone Owned: No

Woman Owned: No

Socially and Economically Disadvantaged: No

Principal Investigator

Name: Wan-Liang Li
Phone: () -

Business Contact

Phone: () -

Research Institution

N/A

Abstract

The goal of this Phase I project is to isolate and characterize new chromosome-specific human repetelements. The resulting probes will be valuable for cytogenetic cancer diagnostics. Our preliminaryrandom amplification of polymorphic DNA (RAPD) is a valuable approach for the discovery of chromosompolymorphic repetitive DNA elements. Phase I will involve systematic and high- throughput employmentgenome-wide search for such elements. The repetitive DNAs will be cloned, then characterized by sequchromosomal localization and sublocalization, heterozygosity determination, evaluation of evolutionadetermination of average copy number. Additionally, Phase I will include modeling cytogenetic analyschromosomal aberrations using chromosome-specific repetitive DNA probes. Our model system will emplorepetitive element mapping to chromosome 20q12, which we discovered in preliminary research using RAprobe in interphase nuclei representing specific hematological malignancies known to have chromosomavicinity

* Information listed above is at the time of submission. *

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Novel Repeat Elements for Genome Analysis